Pseudomonas aeruginosa Host Immune Evasion

Taylor S. Cohen, Dane Parker, Alice Prince

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

The opportunistic pathogen Pseudomonas aeruginosa is a common cause of pneumonia in immunocompromised and mechanically ventilated patients. By virtue of its large genome and genetic flexibility, P. aeruginosa is able to adapt to its environment regulating the expression of a large repertoire of virulence factors.It is capable of forming biofilms that favor persistence and evasion of phagocytic clearance. Within a biofilm the bacteria communicate via soluble quorum sensors regulating production of elastases and proteases. P. aeruginosa is able to modify expression of pathogen associated molecular patterns such that recognition by hosts immune receptors is minimized. The bacteria are also able to subvert the innate immune system through direct interaction with host cells and host immune cytokines. These strategies of immune evasion and the genetic pathways that regulate them have contributed to the unusual success of P. aeruginosa as on opportunistic pathogen.

Original languageEnglish (US)
Title of host publicationPseudomonas
Subtitle of host publicationVolume 7: New Aspects of Pseudomonas Biology
PublisherSpringer Netherlands
Pages3-23
Number of pages21
ISBN (Electronic)9789401795555
ISBN (Print)9789401795548
DOIs
StatePublished - Jan 1 2015

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Immunology and Microbiology(all)

Keywords

  • Biofilm
  • Innate immunity
  • P. Aeruginosa

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