Model intermediates: Catalytic mechanisms of RNA transphosphorylation are investigated by monitoring changes in the reaction rate that occur upon substitution of key phosphate oxygen atoms with sulfur atoms. The mechanisms and barriers to pseudorotation for a series of oxyphosphorane and thiophosphorane molecules are presented (see picture). Theoretical models provide detailed insight into biological phosphorous reactivity in RNA systems.
All Science Journal Classification (ASJC) codes
- Atomic and Molecular Physics, and Optics
- Physical and Theoretical Chemistry
- Density functional calculations
- Model systems
- Phosphorane intermediates
- RNA transphosphorylation