Pseudorotation of natural and chemically modified biological phosphoranes: Implications for RNA catalysis

Carlos Silva López, Olalla Nieto Faza, Brent A. Gregersen, Xabier Lopez, Angel R. De Lera, Darrin M. York

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Model intermediates: Catalytic mechanisms of RNA transphosphorylation are investigated by monitoring changes in the reaction rate that occur upon substitution of key phosphate oxygen atoms with sulfur atoms. The mechanisms and barriers to pseudorotation for a series of oxyphosphorane and thiophosphorane molecules are presented (see picture). Theoretical models provide detailed insight into biological phosphorous reactivity in RNA systems.

Original languageEnglish (US)
Pages (from-to)1045-1049
Number of pages5
JournalChemPhysChem
Volume5
Issue number7
DOIs
StatePublished - Jul 19 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • Physical and Theoretical Chemistry

Keywords

  • Density functional calculations
  • Model systems
  • Phosphorane intermediates
  • Pseudorotation
  • RNA transphosphorylation

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