Pseudorotation of natural and chemically modified biological phosphoranes: Implications for RNA catalysis

Carlos Silva López; Olalla Nieto Faza; Brent A. Gregersen; Xabier Lopez; Angel R. De Lera; Darrin M. York

doi:10.1002/cphc.200400091

Pseudorotation of natural and chemically modified biological phosphoranes: Implications for RNA catalysis

Carlos Silva López, Olalla Nieto Faza, Brent A. Gregersen, Xabier Lopez, Angel R. De Lera, Darrin M. York

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Model intermediates: Catalytic mechanisms of RNA transphosphorylation are investigated by monitoring changes in the reaction rate that occur upon substitution of key phosphate oxygen atoms with sulfur atoms. The mechanisms and barriers to pseudorotation for a series of oxyphosphorane and thiophosphorane molecules are presented (see picture). Theoretical models provide detailed insight into biological phosphorous reactivity in RNA systems.

Original language	English (US)
Pages (from-to)	1045-1049
Number of pages	5
Journal	ChemPhysChem
Volume	5
Issue number	7
DOIs	https://doi.org/10.1002/cphc.200400091
State	Published - Jul 19 2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Atomic and Molecular Physics, and Optics
Physical and Theoretical Chemistry

Keywords

Density functional calculations
Model systems
Phosphorane intermediates
Pseudorotation
RNA transphosphorylation

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10.1002/cphc.200400091

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abstract = "Model intermediates: Catalytic mechanisms of RNA transphosphorylation are investigated by monitoring changes in the reaction rate that occur upon substitution of key phosphate oxygen atoms with sulfur atoms. The mechanisms and barriers to pseudorotation for a series of oxyphosphorane and thiophosphorane molecules are presented (see picture). Theoretical models provide detailed insight into biological phosphorous reactivity in RNA systems.",

keywords = "Density functional calculations, Model systems, Phosphorane intermediates, Pseudorotation, RNA transphosphorylation",

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T2 - Implications for RNA catalysis

AU - Silva López, Carlos

AU - Nieto Faza, Olalla

AU - Gregersen, Brent A.

AU - Lopez, Xabier

AU - De Lera, Angel R.

AU - York, Darrin M.

PY - 2004/7/19

Y1 - 2004/7/19

N2 - Model intermediates: Catalytic mechanisms of RNA transphosphorylation are investigated by monitoring changes in the reaction rate that occur upon substitution of key phosphate oxygen atoms with sulfur atoms. The mechanisms and barriers to pseudorotation for a series of oxyphosphorane and thiophosphorane molecules are presented (see picture). Theoretical models provide detailed insight into biological phosphorous reactivity in RNA systems.

AB - Model intermediates: Catalytic mechanisms of RNA transphosphorylation are investigated by monitoring changes in the reaction rate that occur upon substitution of key phosphate oxygen atoms with sulfur atoms. The mechanisms and barriers to pseudorotation for a series of oxyphosphorane and thiophosphorane molecules are presented (see picture). Theoretical models provide detailed insight into biological phosphorous reactivity in RNA systems.

KW - Density functional calculations

KW - Model systems

KW - Phosphorane intermediates

KW - Pseudorotation

KW - RNA transphosphorylation

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Pseudorotation of natural and chemically modified biological phosphoranes: Implications for RNA catalysis

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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