Psoriasis vulgaris and digestive system disorders: Is there a linkage?

Aldona Pietrzak, Iwona Jastrzȩbska, Grazyna Chodorowska, Ryszard Maciejewski, Ewa Dybiec, Maria Juszkiewicz-Borowiec, Dorota Krasowska, Robert A. Schwartz

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Psoriasis is well-known immune-mediated skin disease often associated with co-morbidities, including dyslipidaemia and obesity. Few reports imply that the disease might be also related to pathology of mucosal surfaces, especially that of the digestive system. The authors present a case of psoriasis and concurrent digestive system abnormalities, and review the literature regarding the topic. A 40-year-old man suffered from an exacerbation of exudative psoriasis for about 6 months. Topical antipsoriatics proved ineffective and the disease gradually progressed to a severe disseminated form. Subsequent detailed examinations revealed persistent gastroduodenitis due to H. pylori infection, pancreatic dysfunction and fatty change of the liver, although the patient denied any gastrointestinal symptoms. As a result appropriate treatment of the diagnosed digestive system disorders was added to topical antipsoriatic therapy. Within 2 weeks of treatment clinical symptoms and laboratory signs showed a marked trend to normalisation. The presented medical history seems to suggest that there may be some kind of interplay between psoriasis and digestive system disorders.

Original languageEnglish (US)
Pages (from-to)517-524
Number of pages8
JournalFolia Histochemica et Cytobiologica
Issue number3
StatePublished - 2009

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology


  • Chronic liver disease
  • Digestive system
  • Gastritis, pancreatitis
  • Psoriasis


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