TY - JOUR
T1 - Pterostilbene is more efficacious than hydroxystilbenes in protecting liver fibrogenesis in a carbon tetracholride-induced rat model
AU - Zhan, Jianfeng
AU - Hu, Ting
AU - Shen, Junfeng
AU - Yang, Guliang
AU - Ho, Chi Tang
AU - Li, Shiming
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2021/9
Y1 - 2021/9
N2 - Stilbene compounds existing in edible berries have attracted much attention due to their efficacious health-promoting properties such as antioxidant, anti-aging, modulation of metabolic diseases and cancer prevention among others. Pterostilbene has superior pharmacokinetic profile over hydroxylated stilbenes such as resveratrol and oxyresveratrol. Hence, the current study was to evaluate the anti-hepatic fibrosis effects of pterostilbene in direct comparison to two hydroxylated stilbene compounds. In a carbon tetrachloride (CCl4) stimulated hepatic fibrosis model, rats were co-administrated with pterostilbene and hydroxystilbene via gavage feeding. Results revealed that stilbenes exerted significant efficacious protective effects against rat liver fibrosis, by reducing the expression levels of α-SMA, desmin, MMP2 and MMP9 and down-regulating the expression ofTGF-β1, phosphorylated Smad1/2 and ERK1/2 in the liver tissue, among which pterostilbene demonstrated much potent preventive activity than the hydroxylated stilbenes.
AB - Stilbene compounds existing in edible berries have attracted much attention due to their efficacious health-promoting properties such as antioxidant, anti-aging, modulation of metabolic diseases and cancer prevention among others. Pterostilbene has superior pharmacokinetic profile over hydroxylated stilbenes such as resveratrol and oxyresveratrol. Hence, the current study was to evaluate the anti-hepatic fibrosis effects of pterostilbene in direct comparison to two hydroxylated stilbene compounds. In a carbon tetrachloride (CCl4) stimulated hepatic fibrosis model, rats were co-administrated with pterostilbene and hydroxystilbene via gavage feeding. Results revealed that stilbenes exerted significant efficacious protective effects against rat liver fibrosis, by reducing the expression levels of α-SMA, desmin, MMP2 and MMP9 and down-regulating the expression ofTGF-β1, phosphorylated Smad1/2 and ERK1/2 in the liver tissue, among which pterostilbene demonstrated much potent preventive activity than the hydroxylated stilbenes.
KW - Hepatic fibrosis
KW - Hydroxystilbene compounds
KW - Pterostilbene
KW - TGF-β/Smad/ERK signaling pathway
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UR - http://www.scopus.com/inward/citedby.url?scp=85108918176&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2021.104604
DO - 10.1016/j.jff.2021.104604
M3 - Article
AN - SCOPUS:85108918176
SN - 1756-4646
VL - 84
JO - Journal of Functional Foods
JF - Journal of Functional Foods
M1 - 104604
ER -