Pyridoxal 5′ phosphate: A selective inhibitor of oncornaviral DNA polymerases

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26 Scopus citations


Pyridoxal 5′ phosphate at concentrations < 0.5 mM inhibits polymerization of deoxynucleoside triphosphate catalysed by variety of DNA polymerases isolated from type C RNA tumor viruses, as well as E. coli, but does not affect the polymerase associated RNase H activity. Both phosphate and aldehyde groups of pyridoxal phosphate are essential for the inhibition which appears to be mediated through the reversible Schiff base.

Original languageEnglish (US)
Pages (from-to)180-187
Number of pages8
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - Jul 12 1976
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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