Quality of life of men treated for localized prostate cancer: Outcomes at 6 and 12 months

Elise L. Lev, Lucille Sanzero Eller, Glen Gejerman, John Kolassa, Joan Colella, Janine Pezzino, Patricia Lane, Ravi Munver, Michael Esposito, John Sheuch, Vincent Lanteri, Ihor Sawczuk

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Goals of work: Treatments for early-stage prostate cancer (PCa) are highly effective; therefore, research studies that explore quality of life (QOL) issues associated with different treatments are important. The purposes of this study were to (a) examine differences among treatment groups of men treated with either radiation therapies or radical prostatectomy for PCa and (b) examine quality of life outcomes over time. Patients and methods: We report outcomes 6 and 12 months after 159 men began treatment for PCa with either one of two types of radiation treatment (intensity-modulated radiation therapy plus high dose rate or intensity-modulated radiation therapy plus seed implantation) or radical prostatectomy. Main results: Significant differences among groups are described. Significant predictors of QOL at 6 months included urinary, bowel, and sexual symptoms, anxiety, depression, problem-focused coping, and physiological self-efficacy. Significant predictors of QOL at 12 months were urinary and bowel symptoms, stress, depression, problem-focused coping, and physiological self-efficacy. Demographic variables, race, and living status were significant predictors of quality of life at 12 months. Conclusions: Physiological symptoms and psychological symptoms were both significant predictors of QOL. The psychological factors that predicted quality of life in this study have potential for intervention and point to the next stage of the research.

Original languageEnglish (US)
Pages (from-to)509-517
Number of pages9
JournalSupportive Care in Cancer
Volume17
Issue number5
DOIs
StatePublished - May 2009

All Science Journal Classification (ASJC) codes

  • Oncology

Keywords

  • Oncology
  • Prostate cancer
  • Quality of life
  • Radiation therapy
  • Radical prostatectomy

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