Quantifying Changes in Brain Function Following Injury via Network Measures

Shiva Salsabilian, Elena Bibineyshvili, David J. Margolis, Laleh Najafizadeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Widefield optical imaging enables longitudinal capturing of the large-scale network activity of the cerebral cortex in awake behaving animals. Utilizing this technique, we investigate how the brain's functional network structure is altered following injury. Cortical activity in transgenic calcium reporter mice expressing GCaMP6s is recorded in two sessions, prior and after inducing the injury. As a quantitative network measure, 'communicability' which is indicative of how easily the information flows between nodes in a network via both direct and indirect paths, is considered. Compared to control subjects, results confirm altered functional network structure after the injury. Links that significantly contribute to the altered connectivity after the injury are spatially localized. It is shown that spectral clustering applied to the communicability networks is capable of distinguishing trials associated with pre-and post-injury sessions, suggesting that this approach can be used as an effective way to track changes in brain networks following the injury, and potentially, towards recovery.

Original languageEnglish (US)
Title of host publication2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages5217-5220
Number of pages4
ISBN (Electronic)9781538613115
DOIs
StatePublished - Jul 2019
Event41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 - Berlin, Germany
Duration: Jul 23 2019Jul 27 2019

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Conference

Conference41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
Country/TerritoryGermany
CityBerlin
Period7/23/197/27/19

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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