TY - JOUR
T1 - Rad23 and Rpn10
T2 - Perennial wallflowers join the mêlée
AU - Madura, Kiran
N1 - Funding Information:
I am grateful for comments from D. Finley, S. Elsasser, R. Deshaies and H. Rao. Studies in the author's laboratory are supported by a grant from the National Institutes of Health (CA83875).
PY - 2004/12
Y1 - 2004/12
N2 - Substrate ubiquitination is highly regulated; by contrast, substrate targeting to the proteasome has been considered a stochastic process that is mediated primarily by high-affinity interaction with multi-ubiquitin chains. However, recent findings have shown that substrate recognition by the proteasome is also regulated, and requires Rad23, Dsk2 and Rpn10. These studies suggest that the engagement of protein ubiquitination and translocation with degradation by the proteasome is coordinated by a series of regulated events.
AB - Substrate ubiquitination is highly regulated; by contrast, substrate targeting to the proteasome has been considered a stochastic process that is mediated primarily by high-affinity interaction with multi-ubiquitin chains. However, recent findings have shown that substrate recognition by the proteasome is also regulated, and requires Rad23, Dsk2 and Rpn10. These studies suggest that the engagement of protein ubiquitination and translocation with degradation by the proteasome is coordinated by a series of regulated events.
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U2 - 10.1016/j.tibs.2004.10.008
DO - 10.1016/j.tibs.2004.10.008
M3 - Short survey
C2 - 15544949
AN - SCOPUS:8544222633
SN - 0968-0004
VL - 29
SP - 637
EP - 640
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 12
ER -