Radiation hybrid mapping of five muscarinic acetylcholine receptor subtype genes in Rattus norvegicus

Jeffrey Tseng, Christy B. Erbe, Anne E. Kwitek, Howard J. Jacob, Paul Popper, Phillip A. Wackym

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Acetylcholine is the main neurotransmitter of the vestibular efferent system and a wide variety of muscarinic and nicotinic acetylcholine receptors are expressed in the vestibular periphery. The role of these receptors and in particular the role of muscarinic acetylcholine receptors in the physiology of the vestibular neuroepithelium is not understood. Congenic and consomic rats are a convenient way to investigate the involvement of candidate genes in the manifestation of defined traits. To use congenic or consomic rats to elucidate the roles of these receptors in vestibular physiology or pathology the chromosomal location of the genes encoding these receptors has to be determined. Using radiation hybrid (RH) mapping and a rat RH map server (www.rgd.mcw.edu/RHMAP SERVER/), we determined the chromosomal locations of the muscarinic acetylcholine receptor genes in the rat (Rattus norvegicus). The m1-m5 muscarinic subtypes mapped to the following chromosomes: Chrm1, chromosome 1; Chrm2, chromosome 4; Chrm3, chromosome 17; Chrm4, chromosome 3; and Chrm5, chromosome 3. With the chromosomal location for each of these muscarinic subtypes known, it is now possible to develop congenic and consomic strains of rats that can be used to study the functions of each of these subtypes.

Original languageEnglish (US)
Pages (from-to)86-92
Number of pages7
JournalHearing Research
Issue number1-2
StatePublished - Dec 2002

All Science Journal Classification (ASJC) codes

  • Sensory Systems


  • Acetylcholine
  • Efferent vestibular system
  • Muscarinic
  • Radiation hybrid mapping
  • Receptor
  • Vestibular


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