Radiotherapy modality as a predictor of survival in hypopharyngeal cancer

Suat Kılıç, Sarah S. Kılıç, Wayne D. Hsueh, Jean Anderson Eloy, Soly Baredes, Richard Chan Woo Park, Omar Mahmoud

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Background: The impact of radiotherapy (RT) modality and dose on survival in hypopharyngeal cancer managed with definitive RT is unclear. Methods: The National Cancer Database was queried for patients with hypopharyngeal squamous cell carcinoma (HPSCC) treated with definitive RT. Intensity-modulated radiotherapy (IMRT) was compared with other RT techniques. Clinicopathologic variables, RT modality, and dose impact on overall survival (OS) were assessed using log-rank test and Cox proportional hazard models. Results: A total of 3928 patients with HPSCC were identified. Patients receiving IMRT (2098 patients) were more likely to be white, have higher income, have advanced classification, receive ≥66 Gy, and receive chemoradiotherapy compared with those receiving non-IMRT techniques (1830 patients). The 5-year OS was 41.9% (95% CI = 39.4%-44.4%) for the IMRT group and 36.8% for the non-IMRT group (95% CI = 34.3%-39.2%). After propensity score matching, IMRT had significantly better OS (P =.013). Conclusion: In HPSCC treated with definitive RT, IMRT may provide a significant survival benefit over non-IMRT modalities.

Original languageEnglish (US)
Pages (from-to)2441-2448
Number of pages8
JournalHead and Neck
Issue number11
StatePublished - Nov 2018

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology


  • IMRT
  • cancer
  • hypopharynx
  • radiation
  • radiotherapy
  • survival


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