Radiotoxicity of gadolinium-148 and radium-223 in mouse testes: Relative biological effectiveness of alpha-particle emitters in vivo

Roger Howell, S. Murty Goddu, Venkat R. Narra, Darrell R. Fisher, Robert E. Schenter, Dandamudi V. Rao

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The biological effects of radionuclides that emit α particles are of considerable interest in view of their potential for therapy and their presence in the environment. The present work is a continuation of our ongoing effort to study the radiotoxicity of α-particle emitters in vivo using the survival of murine testicular sperm heads as the biological end point. Specifically, the relative biological effectiveness (RBE) of very low- energy α particles (3.2 MeV) emitted by 148Gd is investigated and determined to be 7.4 ± 2.4 when compared to the effects of acute external 120 kVp X rays. This datum, in conjunction with our earlier results for 210Po and 212Pb in equilibrium with its daughters, is used to revise and extend the range of validity of our previous RBE-energy relationship for α particles emitted by tissue-incorporated radionuclides. The new empirical relationship is given by RBEα = 9.14 - 0.510 Eα, where 3 < Eα < 9 MeV. The validity of this empirical relationship is tested by determining the RBE of the prolific α-particle emitter 223Ra (in equilibrium with its daughters) experimentally in the same biological model and comparing the value obtained experimentally with the predicted value. The resulting RBE values are 5.4 ± 0.9 and 5.6, respectively. This close agreement strongly supports the adequacy of the empirical RBE-Eα relationship to predict the biological effects of α-particle emitters in vivo.

Original languageEnglish (US)
Pages (from-to)342-348
Number of pages7
JournalRadiation Research
Volume147
Issue number3
DOIs
StatePublished - Mar 22 1997

Fingerprint

Relative Biological Effectiveness
Alpha Particles
testes
Radium
radium
Gadolinium
gadolinium
alpha particles
mice
Testis
emitters
biological effects
Radioisotopes
radioactive isotopes
Sperm Head
bionics
Biological Models
adequacy
particle energy
therapy

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

Cite this

Howell, Roger ; Goddu, S. Murty ; Narra, Venkat R. ; Fisher, Darrell R. ; Schenter, Robert E. ; Rao, Dandamudi V. / Radiotoxicity of gadolinium-148 and radium-223 in mouse testes : Relative biological effectiveness of alpha-particle emitters in vivo. In: Radiation Research. 1997 ; Vol. 147, No. 3. pp. 342-348.
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Radiotoxicity of gadolinium-148 and radium-223 in mouse testes : Relative biological effectiveness of alpha-particle emitters in vivo. / Howell, Roger; Goddu, S. Murty; Narra, Venkat R.; Fisher, Darrell R.; Schenter, Robert E.; Rao, Dandamudi V.

In: Radiation Research, Vol. 147, No. 3, 22.03.1997, p. 342-348.

Research output: Contribution to journalArticle

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T2 - Relative biological effectiveness of alpha-particle emitters in vivo

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