Randomized, phase II study prospectively evaluating treatment of metastatic esophageal, gastric, or gastroesophageal cancer by gene expression of ERCC1: SWOG S1201

Syma Iqbal, Shannon McDonough, Heinz Josef Lenz, David Ilson, Barbara Burtness, Chaitali S. Nangia, Afsaneh Barzi, Charles J. Schneider, Jane Jijun Liu, Efrat Dotan, Katherine A. Guthrie, Howard S. Hochster

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

PURPOSE Platinum-based therapy is the standard of care in patients who have HER2-negative, advanced esophagogastric cancer (AEGC). Retrospective data suggest that intratumoral ERCC1 levels may determine platinum sensitivity. A randomized, phase II study was performed in patients with AEGC to explore whether the efficacy of a platinum-based therapy with fluorouracil, leucovorin, and oxaliplatin (FOLFOX) versus a non-platinum-containing regimen of irinotecan and docetaxel (IT) differed according to ERCC1 levels. PATIENTS AND METHODS Overall, 202 untreated patients with HER2-negative AEGC and a Zubrod performance status of 0-1 were evaluated prospectively for mRNA expression of ERCC1 level and then randomly assigned to FOLFOX or IT, stratified by the intratumoral statuses of ERCC1 low (, 1.7) or high ($ 1.7). Objectives were to assess progression-free survival (PFS) and overall survival (OS) in all patients treated with FOLFOX compared with IT, stratified by low and high ERCC1 levels, and to assess for interactive effects between ERCC1 expression and treatment arm. RESULTS Eighty-six percent of patients had ERCC1 values, 1.7. Thus, evaluation of the ERCC1-high subgroup was limited. Grade $ 3 anemia, dehydration, diarrhea, and fatigue were greater in patients with IT. Occurrences of grade $ 3 neuropathy and decreased neutrophils were greater in patients with FOLFOX. In all patients, FOLFOX had a statistically superior median PFS compared with IT (5.7 v 2.9 months; hazard ratio, 0.68; P = .02). In patients with ERCC1 levels, 1.7 receiving FOLFOX, PFS and response rate were statistically superior to IT, with no significant difference in OS. CONCLUSION The evaluation of ERCC1 in patients with upper GI tumors was thwarted by an overwhelming predominance of low ERCC1 mRNA expression. Nonetheless, distribution of treatment effects on PFS did not vary with expression. For all patients and for those with low ERCC1 expression, FOLFOX was superior in efficacy to IT.

Original languageEnglish (US)
Pages (from-to)472-479
Number of pages8
JournalJournal of Clinical Oncology
Volume38
Issue number5
DOIs
StatePublished - Feb 10 2020

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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