Rapid response to treatment for binge eating disorder

Carlos M. Grilo, Robin M. Masheb, G. Terence Wilson

Research output: Contribution to journalArticle

84 Scopus citations


The authors examined rapid response among 108 patients with binge eating disorder (BED) who were randomly assigned to 1 of 4 16-week treatments: fluoxetine, placebo, cognitive-behavioral therapy (CBT) plus fluoxetine, or CBT plus placebo. Rapid response, defined as 65% or greater reduction in binge eating by the 4th treatment week, was determined by receiver operating characteristic curves. Rapid response characterized 44% of participants and was unrelated to participants' demographic or baseline characteristics. Participants with rapid response were more likely to achieve binge-eating remission, had greater improvements in eating-disorder psychopathology, and had greater weight loss than participants without rapid response. Rapid response had different prognostic significance and distinct time courses for CBT versus pharmacotherapy-only treatments. Rapid response has utility for predicting outcomes and provides evidence for specificity of treatment effects with BED.

Original languageEnglish (US)
Pages (from-to)602-613
Number of pages12
JournalJournal of Consulting and Clinical Psychology
Issue number3
StatePublished - Jun 1 2006


All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health


  • Binge eating disorder
  • Cognitive behavioral therapy
  • Fluoxetine
  • Obesity
  • Rapid response

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