Rapid response to treatment for binge eating disorder

Carlos M. Grilo, Robin M. Masheb, G Wilson

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The authors examined rapid response among 108 patients with binge eating disorder (BED) who were randomly assigned to 1 of 4 16-week treatments: fluoxetine, placebo, cognitive-behavioral therapy (CBT) plus fluoxetine, or CBT plus placebo. Rapid response, defined as 65% or greater reduction in binge eating by the 4th treatment week, was determined by receiver operating characteristic curves. Rapid response characterized 44% of participants and was unrelated to participants' demographic or baseline characteristics. Participants with rapid response were more likely to achieve binge-eating remission, had greater improvements in eating-disorder psychopathology, and had greater weight loss than participants without rapid response. Rapid response had different prognostic significance and distinct time courses for CBT versus pharmacotherapy-only treatments. Rapid response has utility for predicting outcomes and provides evidence for specificity of treatment effects with BED.

Original languageEnglish (US)
Pages (from-to)602-613
Number of pages12
JournalJournal of Consulting and Clinical Psychology
Volume74
Issue number3
DOIs
StatePublished - Jun 1 2006

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Binge-Eating Disorder
Cognitive Therapy
Bulimia
Fluoxetine
Placebos
Therapeutics
Psychopathology
ROC Curve
Weight Loss
Demography
Drug Therapy
Eating Disorders

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Grilo, Carlos M. ; Masheb, Robin M. ; Wilson, G. / Rapid response to treatment for binge eating disorder. In: Journal of Consulting and Clinical Psychology. 2006 ; Vol. 74, No. 3. pp. 602-613.
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Rapid response to treatment for binge eating disorder. / Grilo, Carlos M.; Masheb, Robin M.; Wilson, G.

In: Journal of Consulting and Clinical Psychology, Vol. 74, No. 3, 01.06.2006, p. 602-613.

Research output: Contribution to journalArticle

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