@inproceedings{1288985bff7445119ea525655a212e22,
title = "Rare-earth doped nanocomposites enable multiscale targeted short-wave infrared imaging of metastatic breast cancer",
abstract = "We are investigating the ability of targeted rare earth (RE) doped nanocomposites to detect and track micrometastatic breast cancer lesions to distant sites in pre-clinical in vivo models. Functionalizing RE nanocomposites with AMD3100 promotes targeting to CXCR4, a recognized marker for highly metastatic disease. Mice were inoculated with SCP-28 (CXCR4 positive) and 4175 (CXCR4 negative) cell lines. Whole animal in vivo SWIR fluorescence imaging was performed after bioluminescence imaging confirmed tumor burden in the lungs. Line-scanning confocal fluorescence microscopy provided high-resolution imaging of RE nanocomposite uptake and native tissue autofluorescence in ex vivo lung specimens. Co-registered optical coherence tomography imaging allowed assessment of tissue microarchitecture. In conclusion, multiscale optical molecular imaging can be performed in pre-clinical models of metastatic breast cancer, using targeted RE-doped nanocomposites.",
keywords = "Nanoparticles, SWIR imaging, infrared imaging, microscopy, pre-clinical imaging, upconversion",
author = "Pierce, {Mark C.} and Higgins, {Laura M.} and Vidya Ganapathy and Harini Kantamneni and Riman, {Richard E.} and Roth, {Charles M.} and Moghe, {Prabhas V.}",
note = "Publisher Copyright: {\textcopyright} 2017 SPIE.; Diagnosis and Treatment of Diseases in the Breast and Reproductive System ; Conference date: 28-01-2017 Through 29-01-2017",
year = "2017",
doi = "10.1117/12.2253511",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Campagnola, {Paul J.} and Skala, {Melissa C.}",
booktitle = "Diagnosis and Treatment of Diseases in the Breast and Reproductive System",
address = "United States",
}