Rational inhibitor design and iterative screening in the identification of selective plasmodial cyclin dependent kinase inhibitors

Medicine & Life Sciences

• Cyclin-Dependent Kinases 58%
• Drug Design 57%
• Malaria 45%
• Oxindoles 43%
• Quinolines 42%
• Cyclin-Dependent Kinase Inhibitor Proteins 41%
• Crystallography 35%
• Program Development 31%
• Antimalarials 27%
• Drug Development 23%
• Parasites 20%
• Cell Cycle 19%
• Phosphotransferases 19%
• Amino Acids 17%
• Drug Therapy 14%
• Pharmaceutical Preparations 10%

Engineering & Materials Science

• Cyclin-Dependent Kinases 100%
• Screening 46%
• Crystallography 25%
• Molecular modeling 25%
• Chemotherapy 24%
• Parasites 23%
• Drug Development 23%
• Amino acids 19%
• Assays 19%
• Cells 16%
• Pipelines 12%
• Chemical analysis 10%

Chemical Compounds

• Cyclin Dependent Kinase Inhibitor 80%
• Drug 26%
• Antimalarial Agent 21%
• Oxindoles 20%
• Protein 20%
• Pipeline 19%
• Quinolines 19%
• Drug Target 19%
• Crystallography 17%
• Amino Acid Composition 17%
• Molecular Modeling 14%
• Shape 10%