Recent advances in the chemoselective reduction of functional groups mediated by samarium(ii) iodide: A single electron transfer approach

Michal Szostak, Malcolm Spain, David J. Procter

Research output: Contribution to journalReview article

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Recently, samarium(ii) iodide reductants have emerged as powerful single electron donors for the highly chemoselective reduction of common functional groups. Complete control of the product formation can be achieved on the basis of a judicious choice of a Sm(ii) complex/proton donor couple, even in the presence of extremely sensitive functionalities (iodides, aldehydes). In most cases, the reductions are governed by thermodynamic control of the first electron transfer, which opens up new prospects for unprecedented transformations via radical intermediates under mild regio-, chemo- and diastereoselective conditions that are fully orthogonal to hydrogenation or metal-hydride mediated processes.

Original languageEnglish (US)
Pages (from-to)9155-9183
Number of pages29
JournalChemical Society Reviews
Issue number23
Publication statusPublished - Dec 7 2013
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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