Receptor targeted polymers, dendrimers, liposomes: Which nanocarrier is the most efficient for tumor-specific treatment and imaging?

Maha Saad, Olga B. Garbuzenko, Elizabeth Ber, Pooja Chandna, Jayant J. Khandare, Vitaly P. Pozharov, Tamara Minko

Research output: Contribution to journalArticlepeer-review

189 Scopus citations

Abstract

To compare the influence of different characteristics of nanocarriers on the efficacy of chemotherapy and imaging, we designed, characterized, and evaluated three widely used nanocarriers: linear polymer, dendrimer and liposome in vitro and in vivo. These nanocarriers delivered the same anticancer drug (paclitaxel) and/or imaging agent (Cy5.5). A synthetic analog of LHRH peptide targeted to receptors overexpressed on the membrane of cancer cells was attached to the nanocarriers as a tumor targeting moiety. Significant differences were found between various studied non-targeted carriers in their cellular internalization, cytotoxicity, tumor and organ distribution and anticancer efficacy. LHRH peptide substantially enhanced intratumoral accumulation and anticancer efficacy of all delivery systems and minimized their adverse side effects. For the first time, the present study revealed that the targeting of nanocarriers to tumor-specific receptors minimizes the influence of the architecture, composition, size and molecular mass of nanocarriers on the efficacy of imaging and cancer treatment.

Original languageEnglish (US)
Pages (from-to)107-114
Number of pages8
JournalJournal of Controlled Release
Volume130
Issue number2
DOIs
StatePublished - Sep 10 2008

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Adverse side effects
  • Imaging
  • LHRH peptide
  • Nanocarriers
  • Tumor-specific targeting

Fingerprint Dive into the research topics of 'Receptor targeted polymers, dendrimers, liposomes: Which nanocarrier is the most efficient for tumor-specific treatment and imaging?'. Together they form a unique fingerprint.

Cite this