Recombinant polymers for cancer gene therapy: A minireview

M. Haider, A. Hatefi, H. Ghandehari

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

A major challenge for successful cancer gene therapy is the development of safe and effective gene delivery vectors. Gene delivery vectors can be viral or nonviral. Among nonviral vectors various polymeric vectors have shown potential in gene delivery. However, much work needs to be done in order to correlate polymer structure with gene release at the target site and transfection efficiency. This article is a brief introduction into cancer gene therapy, barriers and methods for gene transfer with emphasis on the applications of recombinant polymers for cancer gene therapy.

Original languageEnglish (US)
Pages (from-to)108-119
Number of pages12
JournalJournal of Controlled Release
Volume109
Issue number1-3
DOIs
StatePublished - Dec 5 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Cancer gene therapy
  • Gene delivery
  • Gene transfer
  • Non-viral vectors
  • Recombinant polymers

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