Recombinant polymers for cancer gene therapy: A minireview

M. Haider; A. Hatefi; H. Ghandehari

doi:10.1016/j.jconrel.2005.09.018

Recombinant polymers for cancer gene therapy: A minireview

M. Haider, A. Hatefi, H. Ghandehari

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A major challenge for successful cancer gene therapy is the development of safe and effective gene delivery vectors. Gene delivery vectors can be viral or nonviral. Among nonviral vectors various polymeric vectors have shown potential in gene delivery. However, much work needs to be done in order to correlate polymer structure with gene release at the target site and transfection efficiency. This article is a brief introduction into cancer gene therapy, barriers and methods for gene transfer with emphasis on the applications of recombinant polymers for cancer gene therapy.

Original language	English (US)
Pages (from-to)	108-119
Number of pages	12
Journal	Journal of Controlled Release
Volume	109
Issue number	1-3
DOIs	https://doi.org/10.1016/j.jconrel.2005.09.018
State	Published - Dec 5 2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

Keywords

Cancer gene therapy
Gene delivery
Gene transfer
Non-viral vectors
Recombinant polymers

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10.1016/j.jconrel.2005.09.018

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title = "Recombinant polymers for cancer gene therapy: A minireview",

abstract = "A major challenge for successful cancer gene therapy is the development of safe and effective gene delivery vectors. Gene delivery vectors can be viral or nonviral. Among nonviral vectors various polymeric vectors have shown potential in gene delivery. However, much work needs to be done in order to correlate polymer structure with gene release at the target site and transfection efficiency. This article is a brief introduction into cancer gene therapy, barriers and methods for gene transfer with emphasis on the applications of recombinant polymers for cancer gene therapy.",

keywords = "Cancer gene therapy, Gene delivery, Gene transfer, Non-viral vectors, Recombinant polymers",

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note = "Funding Information: Financial support was made possible by grants from the NIH (R01CA107621-01), DOD (DAMD17-03-0237 and DMAD17-03-1-0534) and a National Cancer Center Postdoctoral Fellowship (AH). ",

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T2 - A minireview

AU - Haider, M.

AU - Hatefi, A.

AU - Ghandehari, H.

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PY - 2005/12/5

Y1 - 2005/12/5

N2 - A major challenge for successful cancer gene therapy is the development of safe and effective gene delivery vectors. Gene delivery vectors can be viral or nonviral. Among nonviral vectors various polymeric vectors have shown potential in gene delivery. However, much work needs to be done in order to correlate polymer structure with gene release at the target site and transfection efficiency. This article is a brief introduction into cancer gene therapy, barriers and methods for gene transfer with emphasis on the applications of recombinant polymers for cancer gene therapy.

AB - A major challenge for successful cancer gene therapy is the development of safe and effective gene delivery vectors. Gene delivery vectors can be viral or nonviral. Among nonviral vectors various polymeric vectors have shown potential in gene delivery. However, much work needs to be done in order to correlate polymer structure with gene release at the target site and transfection efficiency. This article is a brief introduction into cancer gene therapy, barriers and methods for gene transfer with emphasis on the applications of recombinant polymers for cancer gene therapy.

KW - Cancer gene therapy

KW - Gene delivery

KW - Gene transfer

KW - Non-viral vectors

KW - Recombinant polymers

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ER -

Recombinant polymers for cancer gene therapy: A minireview

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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