Abstract
Major progress has recently been made in the challenging redox-neutral decarbonylative cross-coupling of carboxylic acids. For example, the use of acid fluorides as effective cross-coupling partners has been found to enable control of the decarbonylation selectivity and facilitates challenging Pd0-catalyzed nucleophilic trifluoromethylation and exogenous base-free Suzuki cross-coupling reactions. In another recent advance, the use of acid chlorides in room temperature difluoromethylation and direct decarbonylative cross-coupling of carboxylic acids allows these classical substrates to be used as aryl electrophiles in cross-coupling reactions. Further challenges that are yet to be addressed in redox-neutral decarbonylative cross-couplings are also briefly summarized.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2983-2987 |
| Number of pages | 5 |
| Journal | ChemSusChem |
| Volume | 12 |
| Issue number | 13 |
| DOIs | |
| State | Published - Jul 5 2019 |
All Science Journal Classification (ASJC) codes
- Environmental Chemistry
- Chemical Engineering(all)
- Materials Science(all)
- Energy(all)
Keywords
- arenes
- carboxylic acids
- cross-coupling
- decarbonylation
- homogeneous catalysis