Redox-Neutral Decarbonylative Cross-Couplings Coming of Age

Qun Zhao, Michal Szostak

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Major progress has recently been made in the challenging redox-neutral decarbonylative cross-coupling of carboxylic acids. For example, the use of acid fluorides as effective cross-coupling partners has been found to enable control of the decarbonylation selectivity and facilitates challenging Pd0-catalyzed nucleophilic trifluoromethylation and exogenous base-free Suzuki cross-coupling reactions. In another recent advance, the use of acid chlorides in room temperature difluoromethylation and direct decarbonylative cross-coupling of carboxylic acids allows these classical substrates to be used as aryl electrophiles in cross-coupling reactions. Further challenges that are yet to be addressed in redox-neutral decarbonylative cross-couplings are also briefly summarized.

Original languageEnglish (US)
Pages (from-to)2983-2987
Number of pages5
Issue number13
StatePublished - Jul 5 2019

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Chemical Engineering(all)
  • Materials Science(all)
  • Energy(all)


  • arenes
  • carboxylic acids
  • cross-coupling
  • decarbonylation
  • homogeneous catalysis


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