Reduction of breast density following tamoxifen treatment evaluated by 3-D MRI: Preliminary study

Jeon Hor Chen, Yeun Chung Chang, Daniel Chang, Yi Ting Wang, Ke Nie, Ruey Feng Chang, Orhan Nalcioglu, Chiun Sheng Huang, Min Ying Su

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37 Scopus citations


This study analyzed the change in breast density in women receiving tamoxifen treatment using 3-D MRI. Sixteen women were studied. Each woman received breast MRI before and after tamoxifen. The breast and the fibroglandular tissue were segmented using a computer-assisted algorithm, based on T1-weighted images. The fibroglandular tissue volume (FV) and breast volume (BV) were measured and the ratio was calculated as the percent breast density (%BD). The changes in breast volume (ΔBV), fibroglandular tissue volume (ΔFV) and percent density (Δ%BD) between two MRI studies were analyzed and correlated with treatment duration and baseline breast density. The ΔFV showed a reduction in all 16 women. The Δ%BD showed a mean reduction of 5.8%. The reduction of FV was significantly correlated with baseline FV (P<001) and treatment duration (P=03). The percentage change in FV was correlated with duration (P=049). The reduction in %BD was positively correlated with baseline %BD (P=02). Women with higher baseline %BD showed more reduction of %BD. Three-dimensional MRI may be useful for the measurement of the small changes of ΔFV and Δ%BD after tamoxifen. These changes can potentially be used to correlate with the future reduction of cancer risk.

Original languageEnglish (US)
Pages (from-to)91-98
Number of pages8
JournalMagnetic Resonance Imaging
Issue number1
StatePublished - Jan 2011

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


  • 3D MRI
  • Breast
  • Breast density
  • Fibroglandular tissue
  • Percent breast density
  • Tamoxifen


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