Regression of C6 rat brain tumors by cells expressing an antisense Insulin-like Growth Factor I Receptor RNA

Mariana Resnicoff, Juri Tjuvajev, Harris L. Rotman, David Abraham, Mark Curtis, Robert Aiken, Renato Baserga

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

We have previously shown that C6 cells expressing an antisense insulin-like growth factor I receptor (IGF-IR) RNA are no longer tumorigenic in syngeneic rats, protecting them from subsequent subcutaneous tumor challenge and causing regression of established subcutaneous tumors. In the present study, we have investigated the efficacy of this strategy on intracerebrally implanted C6 rat glioblastoma cells. We demonstrate that C6 cells expressing an antisense IGF-IR RNA implanted for 24 h in the subcutaneous tissue of the rats are able to elicit an anti-tumor response in the brain, leading to complete brain tumor regression and long-term survival of the rats. These findings suggest the possibility of therapeutic intervention in human gliomas.

Original languageEnglish (US)
Pages (from-to)385-389
Number of pages5
JournalJournal of Experimental Therapeutics and Oncology
Volume1
Issue number6
StatePublished - Nov 1996

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Cancer Research

Keywords

  • Antisense
  • Insulin-like growth factor I receptor
  • Tumor regression

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