Regulation of expression of the Borrelia burgdorferi β3-chain integrin ligand, P66, in ticks and in culture

Carla Cugini, Melisa Medrano, Tom G. Schwan, Jenifer Coburn

Research output: Contribution to journalArticle

35 Scopus citations


Borrelia burgdorferi is maintained in an infection cycle between mammalian and arthropod hosts. Appropriate gene expression by B. burgdorferi at different stages of this cycle is probably essential for transmission and establishment of infection. The B. burgdorferi β3 integrin ligand P66 is expressed by the bacteria in mammals, laboratory culture, and engorged but not unfed ticks. No in vitro culture conditions in which P66 expression reflected that in the unfed tick were found, suggesting that there are aspects of B. burgdorferi-tick interaction that remain unexplored.

Original languageEnglish (US)
Pages (from-to)1001-1007
Number of pages7
JournalInfection and immunity
Issue number2
StatePublished - Feb 1 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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