Regulation of Hedgehog Signaling in Cancer by Natural and Dietary Compounds

Cheng Bao, Pavel Kramata, Hong Jin Lee, Nanjoo Suh

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

The aberrant Hedgehog (Hh) signaling induced by mutations or overexpression of the signaling mediators has been implicated in cancer, associated with processes including inflammation, tumor cell growth, invasion, and metastasis, as well as cancer stemness. Small molecules targeting the regulatory components of the Hh signaling pathway, especially Smoothened (Smo), have been developed for the treatment of cancer. However, acquired resistance to a Smo inhibitor vismodegib observed in clinical trials suggests that other Hh signaling components need to be explored as potential anticancer targets. Natural and dietary compounds provide a resource for the development of potent agents affecting intracellular signaling cascades, and numerous studies have been conducted to evaluate the efficacy of natural products in targeting the Hh signaling pathway. In this review, we summarize the role of Hh signaling in tumorigenesis, discuss results from recent studies investigating the effect of natural products and dietary components on Hh signaling in cancer, and provide insight on novel small molecules as potential Hh signaling inhibitors.

Original languageEnglish (US)
Article number1700621
JournalMolecular Nutrition and Food Research
Volume62
Issue number1
DOIs
StatePublished - Jan 1 2018

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Erinaceidae
neoplasms
Neoplasms
Biological Products
HhAntag691
Carcinogenesis
Clinical Trials
Neoplasm Metastasis
metastasis
Inflammation
carcinogenesis
Mutation
cell growth
clinical trials
inflammation
Growth
mutation

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science

Keywords

  • cancer
  • gli
  • hedgehog signaling
  • natural inhibitors

Cite this

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Regulation of Hedgehog Signaling in Cancer by Natural and Dietary Compounds. / Bao, Cheng; Kramata, Pavel; Lee, Hong Jin; Suh, Nanjoo.

In: Molecular Nutrition and Food Research, Vol. 62, No. 1, 1700621, 01.01.2018.

Research output: Contribution to journalReview article

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N2 - The aberrant Hedgehog (Hh) signaling induced by mutations or overexpression of the signaling mediators has been implicated in cancer, associated with processes including inflammation, tumor cell growth, invasion, and metastasis, as well as cancer stemness. Small molecules targeting the regulatory components of the Hh signaling pathway, especially Smoothened (Smo), have been developed for the treatment of cancer. However, acquired resistance to a Smo inhibitor vismodegib observed in clinical trials suggests that other Hh signaling components need to be explored as potential anticancer targets. Natural and dietary compounds provide a resource for the development of potent agents affecting intracellular signaling cascades, and numerous studies have been conducted to evaluate the efficacy of natural products in targeting the Hh signaling pathway. In this review, we summarize the role of Hh signaling in tumorigenesis, discuss results from recent studies investigating the effect of natural products and dietary components on Hh signaling in cancer, and provide insight on novel small molecules as potential Hh signaling inhibitors.

AB - The aberrant Hedgehog (Hh) signaling induced by mutations or overexpression of the signaling mediators has been implicated in cancer, associated with processes including inflammation, tumor cell growth, invasion, and metastasis, as well as cancer stemness. Small molecules targeting the regulatory components of the Hh signaling pathway, especially Smoothened (Smo), have been developed for the treatment of cancer. However, acquired resistance to a Smo inhibitor vismodegib observed in clinical trials suggests that other Hh signaling components need to be explored as potential anticancer targets. Natural and dietary compounds provide a resource for the development of potent agents affecting intracellular signaling cascades, and numerous studies have been conducted to evaluate the efficacy of natural products in targeting the Hh signaling pathway. In this review, we summarize the role of Hh signaling in tumorigenesis, discuss results from recent studies investigating the effect of natural products and dietary components on Hh signaling in cancer, and provide insight on novel small molecules as potential Hh signaling inhibitors.

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