Regulation of Keap1–Nrf2 signaling

The role of epigenetics

David Cheng, Renyi Wu, Yue Guo, Ah-Ng Kong

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (NFE2L2/Nrf2) signaling pathway is a pivotal player in the antioxidant response to oxidative and electrophilic stress and can play a role in many human diseases. Activation or inhibition of Nrf2 has been an approach to treating many diseases such as cancer and regulation of this pathway has been thoroughly studied. Recently, epigenetics has emerged as another layer for regulating Keap1–Nrf2. Epigenetics modification is defined as heritable changes to gene expression without changing DNA sequence and various modifications have been found to be involved in regulating Keap1–Nrf2. Therefore, targeting these epigenetic changes on Keap1–Nrf2 provides a potential pathway for modulating Keap1–Nrf2 to treat disease. In this review, several important and recent findings on epigenetic regulation and perspectives on Keap1–Nrf2 are discussed and shared.

Original languageEnglish (US)
Pages (from-to)134-138
Number of pages5
JournalCurrent Opinion in Toxicology
Volume1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Epigenomics
GATA1 Transcription Factor
DNA sequences
Gene expression
Antioxidants
Chemical activation
Oxidative Stress
Gene Expression
Proteins
Neoplasms

All Science Journal Classification (ASJC) codes

  • Toxicology

Keywords

  • DNA methylation
  • Epigenetics
  • Histone modifications
  • Keap1
  • Nrf2
  • Oxidative stress
  • miRNAs

Cite this

Cheng, David ; Wu, Renyi ; Guo, Yue ; Kong, Ah-Ng. / Regulation of Keap1–Nrf2 signaling : The role of epigenetics. In: Current Opinion in Toxicology. 2016 ; Vol. 1. pp. 134-138.
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Regulation of Keap1–Nrf2 signaling : The role of epigenetics. / Cheng, David; Wu, Renyi; Guo, Yue; Kong, Ah-Ng.

In: Current Opinion in Toxicology, Vol. 1, 01.01.2016, p. 134-138.

Research output: Contribution to journalReview article

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T2 - The role of epigenetics

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AU - Wu, Renyi

AU - Guo, Yue

AU - Kong, Ah-Ng

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AB - Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (NFE2L2/Nrf2) signaling pathway is a pivotal player in the antioxidant response to oxidative and electrophilic stress and can play a role in many human diseases. Activation or inhibition of Nrf2 has been an approach to treating many diseases such as cancer and regulation of this pathway has been thoroughly studied. Recently, epigenetics has emerged as another layer for regulating Keap1–Nrf2. Epigenetics modification is defined as heritable changes to gene expression without changing DNA sequence and various modifications have been found to be involved in regulating Keap1–Nrf2. Therefore, targeting these epigenetic changes on Keap1–Nrf2 provides a potential pathway for modulating Keap1–Nrf2 to treat disease. In this review, several important and recent findings on epigenetic regulation and perspectives on Keap1–Nrf2 are discussed and shared.

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