Regulation of organic anion transporters: Role in physiology, pathophysiology, and drug elimination

Jinghui Zhang, Haoxun Wang, Yunzhou Fan, Zhou Yu, Guofeng You

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

The members of the organic anion transporter (OAT) family are mainly expressed in kidney, liver, placenta, intestine, and brain. These transporters play important roles in the disposition of clinical drugs, pesticides, signaling molecules, heavy metal conjugates, components of phytomedicines, and toxins, and therefore critical for maintaining systemic homeostasis. Alterations in the expression and function of OATs contribute to the intra- and inter-individual variability of the therapeutic efficacy and the toxicity of many drugs, and to many pathophysiological conditions. Consequently, the activity of these transporters must be highly regulated to carry out their normal functions. This review will present an update on the recent advance in understanding the cellular and molecular mechanisms underlying the regulation of renal OATs, emphasizing on the post-translational modification (PTM), the crosstalk among these PTMs, and the remote sensing and signaling network of OATs. Such knowledge will provide significant insights into the roles of these transporters in health and disease.

Original languageEnglish (US)
Article number107647
JournalPharmacology and Therapeutics
Volume217
DOIs
StatePublished - Jan 2021

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Keywords

  • Drug disposition
  • Drug transporter
  • Organic anion transporter
  • Post-translational modification
  • Regulation

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