Regulation of phospholipid synthesis in the yeast Saccharomyces Cerevisiae

George M. Carman, Gil Soo Han

Research output: Contribution to journalArticlepeer-review

180 Scopus citations


The yeast Saccharomyces cerevisiae, with its full complement of organelles, synthesizes membrane phospholipids by pathways that are generally common to those found in higher eukaryotes. Phospholipid synthesis in yeast is regulated in response to a variety of growth conditions (e.g., inositol supplementation, zinc depletion, and growth stage) by a coordination of genetic (e.g., transcriptional activation and repression) and biochemical (e.g., activity modulation and localization) mechanisms. Phosphatidate (PA), whose cellular levels are controlled by the activities of key phospholipid synthesis enzymes, plays a central role in the transcriptional regulation of phospholipid synthesis genes. In addition to the regulation of gene expression, phosphorylation of key phospholipid synthesis catalytic and regulatory proteins controls the metabolism of phospholipid precursors and products.

Original languageEnglish (US)
Pages (from-to)859-883
Number of pages25
JournalAnnual review of biochemistry
StatePublished - Jul 7 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry


  • inositol
  • membranes
  • phosphatidate
  • phosphorylation
  • zinc


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