Regulation of TRP channels by PIP2

Tibor Rohacs

doi:10.1007/s00424-006-0153-7

Regulation of TRP channels by PIP₂

Tibor Rohacs

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Abstract

Transient receptor potential (TRP) channels are regulated by a wide variety of physical and chemical factors. Recently, several members of the TRP channel family were reported to be regulated by phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P₂, PIP₂). This review will summarize the current knowledge on PIP₂ regulation of TRP channels and discuss the possibility that PIP₂ is a common regulator of mammalian TRP channels.

Original language	English (US)
Pages (from-to)	753-762
Number of pages	10
Journal	Pflugers Archiv European Journal of Physiology
Volume	453
Issue number	6
DOIs	https://doi.org/10.1007/s00424-006-0153-7
State	Published - Mar 2007

All Science Journal Classification (ASJC) codes

Physiology
Clinical Biochemistry
Physiology (medical)

Keywords

Ion channels
PIP
Phosphoinositides
PtdIns(4,5)P
TRP channels
TRPC channels
TRPM channels
TRPV channels

Access to Document

10.1007/s00424-006-0153-7

Cite this

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keywords = "Ion channels, PIP, Phosphoinositides, PtdIns(4,5)P, TRP channels, TRPC channels, TRPM channels, TRPV channels",

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AB - Transient receptor potential (TRP) channels are regulated by a wide variety of physical and chemical factors. Recently, several members of the TRP channel family were reported to be regulated by phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2, PIP2). This review will summarize the current knowledge on PIP2 regulation of TRP channels and discuss the possibility that PIP2 is a common regulator of mammalian TRP channels.

KW - Ion channels

KW - PIP

KW - Phosphoinositides

KW - PtdIns(4,5)P

KW - TRP channels

KW - TRPC channels

KW - TRPM channels

KW - TRPV channels

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