Regulation of TRPM8 channel activity

Yevgen Yudin, Tibor Rohacs

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


Transient Receptor Potential Melastatin 8 (TRPM8) is a Ca 2+ permeable non-selective cation channel directly activated by cold temperatures and chemical agonists such as menthol. It is a well established sensor of environmental cold temperatures, found in peripheral sensory neurons, where its activation evokes depolarization and action potentials. The activity of TRPM8 is regulated by a number of cellular signaling pathways, most notably by phosphoinositides and the activation of phospholipase C. This review will summarize current knowledge on the physiological and pathophysiological roles of TRPM8 and its regulation by various intracellular messenger molecules and signaling pathways.

Original languageEnglish (US)
Pages (from-to)68-74
Number of pages7
JournalMolecular and Cellular Endocrinology
Issue number1-2
StatePublished - Apr 28 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology


  • PIP
  • PtdIns(4,5)P
  • TRP channel
  • TRPM8
  • Temperature sensation

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