Abstract
Although colonization with any Helicobacter pylori strain is associated with peptic ulcer, it is uncertain whether the risk is greater with cagA+ or cagA- strains, which differ in their biology. A nested case-control study was done, based on a cohort of 5,443 Japanese-American men examined on the Hawaiian island of Oahu from 1967 to 1970. A total of 150 men with gastric ulcer, 65 with duodenal ulcer, and 14 with both diseases were identified. The authors matched the 229 cases with 229 population controls and tested their serum for immunoglobulin G antibodies to H. pylori and immunoglobulin G antibodies to the cagA product of H. pylori using enzyme-linked immunosorbent assays. Persons with H. pylori positivity had an odds ratio of 4.0 (95% confidence interval (CI): 1.9, 8.5) for gastric ulcer and 2.5 (95% CI: 0.8, 7.4) for duodenal ulcer. For CagA positivity, the odds ratios were 1.4 (95% CI: 0.9, 2.4) for gastric ulcer and 2.6 (95% CI: 1.1, 5.8) for duodenal ulcer. Subjects who were seropositive for both H. pylori and CagA had an odds ratio of 4.4 (95% CI: 1.8, 10.5) for gastric ulcer and 5.8 (95% CI: 1.1, 30.0) for duodenal ulcer. The results suggest that colonization with a cag+ H. pylori strain elevates the risk beyond that of a cag- H. pylori strain for both gastric and duodenal ulcers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1054-1059 |
| Number of pages | 6 |
| Journal | American journal of epidemiology |
| Volume | 155 |
| Issue number | 11 |
| DOIs | |
| State | Published - Jun 1 2002 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Epidemiology
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Relation between Helicobacter pylori cagA status and risk of peptic ulcer disease. / Nomura, Abraham M.Y.; Ṕrez-Ṕrez, Guillermo I.; Lee, James; Stemmermann, Grant; Blaser, Martin.
In: American journal of epidemiology, Vol. 155, No. 11, 01.06.2002, p. 1054-1059.Research output: Contribution to journal › Article
TY - JOUR
T1 - Relation between Helicobacter pylori cagA status and risk of peptic ulcer disease
AU - Nomura, Abraham M.Y.
AU - Ṕrez-Ṕrez, Guillermo I.
AU - Lee, James
AU - Stemmermann, Grant
AU - Blaser, Martin
PY - 2002/6/1
Y1 - 2002/6/1
N2 - Although colonization with any Helicobacter pylori strain is associated with peptic ulcer, it is uncertain whether the risk is greater with cagA+ or cagA- strains, which differ in their biology. A nested case-control study was done, based on a cohort of 5,443 Japanese-American men examined on the Hawaiian island of Oahu from 1967 to 1970. A total of 150 men with gastric ulcer, 65 with duodenal ulcer, and 14 with both diseases were identified. The authors matched the 229 cases with 229 population controls and tested their serum for immunoglobulin G antibodies to H. pylori and immunoglobulin G antibodies to the cagA product of H. pylori using enzyme-linked immunosorbent assays. Persons with H. pylori positivity had an odds ratio of 4.0 (95% confidence interval (CI): 1.9, 8.5) for gastric ulcer and 2.5 (95% CI: 0.8, 7.4) for duodenal ulcer. For CagA positivity, the odds ratios were 1.4 (95% CI: 0.9, 2.4) for gastric ulcer and 2.6 (95% CI: 1.1, 5.8) for duodenal ulcer. Subjects who were seropositive for both H. pylori and CagA had an odds ratio of 4.4 (95% CI: 1.8, 10.5) for gastric ulcer and 5.8 (95% CI: 1.1, 30.0) for duodenal ulcer. The results suggest that colonization with a cag+ H. pylori strain elevates the risk beyond that of a cag- H. pylori strain for both gastric and duodenal ulcers.
AB - Although colonization with any Helicobacter pylori strain is associated with peptic ulcer, it is uncertain whether the risk is greater with cagA+ or cagA- strains, which differ in their biology. A nested case-control study was done, based on a cohort of 5,443 Japanese-American men examined on the Hawaiian island of Oahu from 1967 to 1970. A total of 150 men with gastric ulcer, 65 with duodenal ulcer, and 14 with both diseases were identified. The authors matched the 229 cases with 229 population controls and tested their serum for immunoglobulin G antibodies to H. pylori and immunoglobulin G antibodies to the cagA product of H. pylori using enzyme-linked immunosorbent assays. Persons with H. pylori positivity had an odds ratio of 4.0 (95% confidence interval (CI): 1.9, 8.5) for gastric ulcer and 2.5 (95% CI: 0.8, 7.4) for duodenal ulcer. For CagA positivity, the odds ratios were 1.4 (95% CI: 0.9, 2.4) for gastric ulcer and 2.6 (95% CI: 1.1, 5.8) for duodenal ulcer. Subjects who were seropositive for both H. pylori and CagA had an odds ratio of 4.4 (95% CI: 1.8, 10.5) for gastric ulcer and 5.8 (95% CI: 1.1, 30.0) for duodenal ulcer. The results suggest that colonization with a cag+ H. pylori strain elevates the risk beyond that of a cag- H. pylori strain for both gastric and duodenal ulcers.
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UR - http://www.scopus.com/inward/citedby.url?scp=0036605498&partnerID=8YFLogxK
U2 - 10.1093/aje/155.11.1054
DO - 10.1093/aje/155.11.1054
M3 - Article
C2 - 12034584
AN - SCOPUS:0036605498
VL - 155
SP - 1054
EP - 1059
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 11
ER -