Relation between Helicobacter pylori cagA status and risk of peptic ulcer disease

Abraham M.Y. Nomura, Guillermo I. Ṕrez-Ṕrez, James Lee, Grant Stemmermann, Martin J. Blaser

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107 Scopus citations


Although colonization with any Helicobacter pylori strain is associated with peptic ulcer, it is uncertain whether the risk is greater with cagA+ or cagA- strains, which differ in their biology. A nested case-control study was done, based on a cohort of 5,443 Japanese-American men examined on the Hawaiian island of Oahu from 1967 to 1970. A total of 150 men with gastric ulcer, 65 with duodenal ulcer, and 14 with both diseases were identified. The authors matched the 229 cases with 229 population controls and tested their serum for immunoglobulin G antibodies to H. pylori and immunoglobulin G antibodies to the cagA product of H. pylori using enzyme-linked immunosorbent assays. Persons with H. pylori positivity had an odds ratio of 4.0 (95% confidence interval (CI): 1.9, 8.5) for gastric ulcer and 2.5 (95% CI: 0.8, 7.4) for duodenal ulcer. For CagA positivity, the odds ratios were 1.4 (95% CI: 0.9, 2.4) for gastric ulcer and 2.6 (95% CI: 1.1, 5.8) for duodenal ulcer. Subjects who were seropositive for both H. pylori and CagA had an odds ratio of 4.4 (95% CI: 1.8, 10.5) for gastric ulcer and 5.8 (95% CI: 1.1, 30.0) for duodenal ulcer. The results suggest that colonization with a cag+ H. pylori strain elevates the risk beyond that of a cag- H. pylori strain for both gastric and duodenal ulcers.

Original languageEnglish (US)
Pages (from-to)1054-1059
Number of pages6
JournalAmerican journal of epidemiology
Issue number11
StatePublished - Jun 1 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Epidemiology


  • Duodenal ulcer
  • Helicobacter pylori
  • Peptic ulcer
  • Stomach ulcer

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