Relation between Helicobacter pylori cagA status and risk of peptic ulcer disease

Abraham M.Y. Nomura, Guillermo I. Ṕrez-Ṕrez, James Lee, Grant Stemmermann, Martin Blaser

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Although colonization with any Helicobacter pylori strain is associated with peptic ulcer, it is uncertain whether the risk is greater with cagA+ or cagA- strains, which differ in their biology. A nested case-control study was done, based on a cohort of 5,443 Japanese-American men examined on the Hawaiian island of Oahu from 1967 to 1970. A total of 150 men with gastric ulcer, 65 with duodenal ulcer, and 14 with both diseases were identified. The authors matched the 229 cases with 229 population controls and tested their serum for immunoglobulin G antibodies to H. pylori and immunoglobulin G antibodies to the cagA product of H. pylori using enzyme-linked immunosorbent assays. Persons with H. pylori positivity had an odds ratio of 4.0 (95% confidence interval (CI): 1.9, 8.5) for gastric ulcer and 2.5 (95% CI: 0.8, 7.4) for duodenal ulcer. For CagA positivity, the odds ratios were 1.4 (95% CI: 0.9, 2.4) for gastric ulcer and 2.6 (95% CI: 1.1, 5.8) for duodenal ulcer. Subjects who were seropositive for both H. pylori and CagA had an odds ratio of 4.4 (95% CI: 1.8, 10.5) for gastric ulcer and 5.8 (95% CI: 1.1, 30.0) for duodenal ulcer. The results suggest that colonization with a cag+ H. pylori strain elevates the risk beyond that of a cag- H. pylori strain for both gastric and duodenal ulcers.

Original languageEnglish (US)
Pages (from-to)1054-1059
Number of pages6
JournalAmerican journal of epidemiology
Volume155
Issue number11
DOIs
StatePublished - Jun 1 2002
Externally publishedYes

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Peptic Ulcer
Helicobacter pylori
Stomach Ulcer
Duodenal Ulcer
Confidence Intervals
Odds Ratio
Immunoglobulin G
Population Control
Asian Americans
Antibodies
Islands
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Serum

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Nomura, Abraham M.Y. ; Ṕrez-Ṕrez, Guillermo I. ; Lee, James ; Stemmermann, Grant ; Blaser, Martin. / Relation between Helicobacter pylori cagA status and risk of peptic ulcer disease. In: American journal of epidemiology. 2002 ; Vol. 155, No. 11. pp. 1054-1059.
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Relation between Helicobacter pylori cagA status and risk of peptic ulcer disease. / Nomura, Abraham M.Y.; Ṕrez-Ṕrez, Guillermo I.; Lee, James; Stemmermann, Grant; Blaser, Martin.

In: American journal of epidemiology, Vol. 155, No. 11, 01.06.2002, p. 1054-1059.

Research output: Contribution to journalArticle

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