Relationship of Normal Serum Vitamin B12 and Folate Levels to Cognitive Test Performance in Subtypes of Geriatric Major Depression

Iris R. Bell; Joel S. Edman; Joshua Miller; Nancy Hebben; Richard T. Linn; Diane Ray; Herbert L. Kayne

doi:10.1177/089198879000300208

Relationship of Normal Serum Vitamin B¹² and Folate Levels to Cognitive Test Performance in Subtypes of Geriatric Major Depression

Iris R. Bell, Joel S. Edman, Joshua Miller, Nancy Hebben, Richard T. Linn, Diane Ray, Herbert L. Kayne

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

This retrospective study evaluated the relationships between normal serum vitamin B12 and folate levels and neuropsy chologic measures in a sample of 60 geriatric inpatients with psychotic depression, nonpsychotic depression, bipolar dis order, and dementia—all consecutively referred for cognitive testing. The psychotic depression subgroup demonstrated numerous significant positive correlations between B12 and cognitive subtests not seen in other diagnostic subgroups, especially those of IQ, and verbal and visual memory. Metabolic factors including vitamin B12 may play specific roles in the cognitive dysfunctions of different geropsychiatric disorders.

Original language	English (US)
Pages (from-to)	98-105
Number of pages	8
Journal	Journal of Geriatric Psychiatry and Neurology
Volume	3
Issue number	2
DOIs	https://doi.org/10.1177/089198879000300208
State	Published - Apr 1990
Externally published	Yes

All Science Journal Classification (ASJC) codes

Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health

Access to Document

10.1177/089198879000300208

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title = "Relationship of Normal Serum Vitamin B12 and Folate Levels to Cognitive Test Performance in Subtypes of Geriatric Major Depression",

abstract = "This retrospective study evaluated the relationships between normal serum vitamin B12 and folate levels and neuropsy chologic measures in a sample of 60 geriatric inpatients with psychotic depression, nonpsychotic depression, bipolar dis order, and dementia—all consecutively referred for cognitive testing. The psychotic depression subgroup demonstrated numerous significant positive correlations between B12 and cognitive subtests not seen in other diagnostic subgroups, especially those of IQ, and verbal and visual memory. Metabolic factors including vitamin B12 may play specific roles in the cognitive dysfunctions of different geropsychiatric disorders.",

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Relationship of Normal Serum Vitamin B¹² and Folate Levels to Cognitive Test Performance in Subtypes of Geriatric Major Depression. / Bell, Iris R.; Edman, Joel S.; Miller, Joshua; Hebben, Nancy; Linn, Richard T.; Ray, Diane; Kayne, Herbert L.

In: Journal of Geriatric Psychiatry and Neurology, Vol. 3, No. 2, 04.1990, p. 98-105.

Research output: Contribution to journal › Article › peer-review

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