Remarks on feedforward circuits, adaptation, and pulse memory

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This note studies feedforward circuits as models for perfect adaptation to step signals in biological systems. A global convergence theorem is proved in a general framework, which includes examples from the literature as particular cases. A notable aspect of these circuits is that they do not adapt to pulse signals, because they display a memory phenomenon. Estimates are given of the magnitude of this effect.

Original languageEnglish (US)
Article numberISBEAT000004000001000039000001
Pages (from-to)39-51
Number of pages13
JournalIET Systems Biology
Issue number1
StatePublished - Jan 1 2010

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Modeling and Simulation
  • Molecular Biology
  • Genetics
  • Cell Biology

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