Renal failure and platinum pharmacokinetics in three patients treated with cis-diamminedichloroplatinum(II) and whole-body hyperthermia

Henry Gerad, Merrill J. Egorin, Margaret Whitacre, David A. Van Echo, Joseph Aisner

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Three patients with advanced refractory malignancies were treated with whole-body hyperthermia (WBH: 42-42.3° C) for 2 h during which time they also received an infusion of 60 or 80 mg/m2 of cis-diamminedichloroplatinum II (DDP). Each patient developed an elevated serum creatinine (2.7-13.6 mg/dl), with maximum creatinine occurring between days 7 and 12 after treatment. WBH did not alter plasma or urinary pharmacokinetics of total or ultrafilterable platinum compared with pharmacokinetic data of the same or other patients given DDP euthermically. Although the mechanism of the renal damage is unclear, it appears that WBH can potentiate the nephrotoxic actions of DDP and that further study of this combination is not warranted.

Original languageEnglish (US)
Pages (from-to)162-166
Number of pages5
JournalCancer chemotherapy and pharmacology
Volume11
Issue number3
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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