Reprogramming of intestinal glucose metabolism and glycemic control in rats after gastric bypass

Nima Saeidi, Luca Meoli, Eirini Nestoridi, Nitin K. Gupta, Stephanie Kvas, John Kucharczyk, Ali A. Bonab, Alan J. Fischman, Martin L. Yarmush, Nicholas Stylopoulos

Research output: Contribution to journalArticlepeer-review

236 Scopus citations

Abstract

The resolution of type 2 diabetes after Roux-en-Y gastric bypass (RYGB) attests to the important role of the gastrointestinal tract in glucose homeostasis. Previous studies in RYGB-treated rats have shown that the Roux limb displays hyperplasia and hypertrophy. Here, we report that the Roux limb of RYGB-treated rats exhibits reprogramming of intestinal glucose metabolism to meet its increased bioenergetic demands; glucose transporter-1 is up-regulated, basolateral glucose uptake is enhanced, aerobic glycolysis is augmented, and glucose is directed toward metabolic pathways that support tissue growth. We show that reprogramming of intestinal glucose metabolism is triggered by the exposure of the Roux limb to undigested nutrients. We demonstrate by positron emission tomography-computed tomography scanning and biodistribution analysis using 2-deoxy-2-[18F]fluoro-D-glucose that reprogramming of intestinal glucose metabolism renders the intestine a major tissue for glucose disposal, contributing to the improvement in glycemic control after RYGB.

Original languageEnglish (US)
Pages (from-to)406-410
Number of pages5
JournalScience
Volume341
Issue number6144
DOIs
StatePublished - 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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