@article{e61bb30ff7aa43be99cdf01aa3608e69,
title = "Requirement for phosphorylation and localization of the Bicaudal-D protein in Drosophila oocyte differentiation",
abstract = "In the Drosophila female the product of the germline stem cell, the cystoblast, gives rise to 16 interconnected cystocytes. One of them differentiates into the oocyte, while the 15 others become polyploid nurse cells. Bic-D is required for the differentiation of an oocyte and hence for fertility. Recessive mutations in Bic-D block the oocyte-specific accumulation of its own and other RNAs. Based on its properties and distribution, the Bic-D protein appears to be a component of a cytoskeletal transport or anchoring system. Additional results suggest that the phosphorylation of the Bic-D protein is essential for its accumulation in the pro-oocyte and that this process leads to the gradual localization to the pro-oocyte of factors required for oocyte differentiation.",
author = "Beat Suter and Ruth Steward",
note = "Funding Information: We are indebted to Rita Bopp for excellent technical assistance, to Marty Marlow for help in preparing monoclonal antibodies, to Bill Theur-kauf for communicating his exciting results, and to Anne Ephrussi for providing us with oskar DNA prior to publication. We gratefully thank Paul Schedl for his interest, enthusiasm, and support, and Trudi Schtipbach and Eric Wieschaus for stimulating discussions and for critical reading of the manuscript. Our thanks also go to the former and present members of the Schedl and Steward labs for numerous ideas and discussions, particularly to Linda Keyes, Daniel Bopp, Shubha Govind, Jamila Horabin, Valerie Lantz, and Anne Whalen. We thank G. Gray for fly food and the Horace W. Goldsmith Foundation for support. 8. Suter was supported in part by a fellowship from the Swiss National Science Foundation. This work was supported by grants from the National Institutes of Health.",
year = "1991",
month = nov,
day = "29",
doi = "10.1016/0092-8674(91)90365-6",
language = "English (US)",
volume = "67",
pages = "917--926",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "5",
}