Resistance of the female, as opposed to the male, intestine to I/R-mediated injury is associated with increased resistance to gut-induced distant organ injury

Edwin A. Deitch, Eleonora Feketeova, Qi Lu, Sergy Zaets, Tamara L. Berezina, George W. MacHiedo, Carl J. Hauser, David H. Livingston, Da Zhong Xu

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

We tested the hypothesis that the female intestine is more resistant to gut I/R injury than the male intestine by comparing the effects of the isolated pure gut I/R superior mesenteric artery occlusion (SMAO) model on gut morphology and whether SMAO-induced distant organ injury (lung, bone marrow [BM], neutrophils, and red blood cells [RBCs]) would differ between male and proestrus female rats. At 6 or 24 h after SMAO or sham SMAO, gut injury, lung permeability, pulmonary neutrophil sequestration, RBC deformability, and BM RBC and white blood cell progenitor growth were measured, as was the ability of the plasma from these rats to activate naive rat neutrophils. At both 6 and 24 h after SMAO, the female rats had significantly less intestinal injury and reduced gut-induced lung injury, BM suppression, RBC dysfunction, and neutrophil activation than male rats subjected to SMAO. These results indicate that the resistance of proestrus female rats to gut injury and gut-induced distant organ injury is greater than that observed in male rats.

Original languageEnglish (US)
Pages (from-to)78-83
Number of pages6
JournalShock
Volume29
Issue number1
DOIs
StatePublished - Jan 2008

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

Keywords

  • Bone marrow dysfunction
  • Lung injury
  • RBC dysfunction
  • Sex
  • Superior mesenteric artery occlusion

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