TY - JOUR
T1 - Resistance of the female, as opposed to the male, intestine to I/R-mediated injury is associated with increased resistance to gut-induced distant organ injury
AU - Deitch, Edwin A.
AU - Feketeova, Eleonora
AU - Lu, Qi
AU - Zaets, Sergy
AU - Berezina, Tamara L.
AU - MacHiedo, George W.
AU - Hauser, Carl J.
AU - Livingston, David H.
AU - Xu, Da Zhong
PY - 2008/1
Y1 - 2008/1
N2 - We tested the hypothesis that the female intestine is more resistant to gut I/R injury than the male intestine by comparing the effects of the isolated pure gut I/R superior mesenteric artery occlusion (SMAO) model on gut morphology and whether SMAO-induced distant organ injury (lung, bone marrow [BM], neutrophils, and red blood cells [RBCs]) would differ between male and proestrus female rats. At 6 or 24 h after SMAO or sham SMAO, gut injury, lung permeability, pulmonary neutrophil sequestration, RBC deformability, and BM RBC and white blood cell progenitor growth were measured, as was the ability of the plasma from these rats to activate naive rat neutrophils. At both 6 and 24 h after SMAO, the female rats had significantly less intestinal injury and reduced gut-induced lung injury, BM suppression, RBC dysfunction, and neutrophil activation than male rats subjected to SMAO. These results indicate that the resistance of proestrus female rats to gut injury and gut-induced distant organ injury is greater than that observed in male rats.
AB - We tested the hypothesis that the female intestine is more resistant to gut I/R injury than the male intestine by comparing the effects of the isolated pure gut I/R superior mesenteric artery occlusion (SMAO) model on gut morphology and whether SMAO-induced distant organ injury (lung, bone marrow [BM], neutrophils, and red blood cells [RBCs]) would differ between male and proestrus female rats. At 6 or 24 h after SMAO or sham SMAO, gut injury, lung permeability, pulmonary neutrophil sequestration, RBC deformability, and BM RBC and white blood cell progenitor growth were measured, as was the ability of the plasma from these rats to activate naive rat neutrophils. At both 6 and 24 h after SMAO, the female rats had significantly less intestinal injury and reduced gut-induced lung injury, BM suppression, RBC dysfunction, and neutrophil activation than male rats subjected to SMAO. These results indicate that the resistance of proestrus female rats to gut injury and gut-induced distant organ injury is greater than that observed in male rats.
KW - Bone marrow dysfunction
KW - Lung injury
KW - RBC dysfunction
KW - Sex
KW - Superior mesenteric artery occlusion
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UR - http://www.scopus.com/inward/citedby.url?scp=37549043869&partnerID=8YFLogxK
U2 - 10.1097/shk.0b013e318063e98a
DO - 10.1097/shk.0b013e318063e98a
M3 - Article
C2 - 17666951
AN - SCOPUS:37549043869
VL - 29
SP - 78
EP - 83
JO - Shock
JF - Shock
SN - 1073-2322
IS - 1
ER -