Resistance to transforming growth factor β-mediated tumor suppression in melanoma: Are multiple mechanisms in place?

Ahmed Lasfar, Karine A. Cohen-Solal

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

Resistance to transforming growth factor (TGF) β-mediated tumor suppression in melanoma appears to be a crucial step in tumor aggressiveness since it is usually coupled with the ability of TGFβ to drive the oncogenic process via autocrine and paracrine effects. In this review, we will focus mainly on the mechanisms of escape from TGFβ-induced cell cycle arrest because the mechanisms of resistance to TGFβ-mediated apoptosis are still essentially speculative. As expected, some of these mechanisms can directly affect the function of the main downstream effectors of TGFβ, Smad2 and Smad3, resulting in compromised Smad-mediated antiproliferative activity. Other mechanisms can counteract or overcome TGFβ-mediated cell cycle arrest independently of the Smads. In melanoma, some models of resistance to TGFβ have been suggested and will be described. In addition, we propose additional models of resistance taking into consideration the information available on the dysregulation of fundamental cellular effectors and signaling pathways in melanoma.

Original languageEnglish (US)
Pages (from-to)1710-1717
Number of pages8
JournalCarcinogenesis
Volume31
Issue number10
DOIs
StatePublished - Jul 23 2010

All Science Journal Classification (ASJC) codes

  • Cancer Research

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