Respiratory and autonomic dysfunction in children with autism spectrum disorders

Xue Ming, Ritesh Patel, Victor Kang, Sudhansu Chokroverty, Peter O. Julu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Introduction: Cardiac parasympathetic hypofunction has been reported in autism spectrum disorders (ASD). This usually is linked to respiratory dysrhythmia which has been documented in some children with ASD. Objectives: This study evaluated the cardiorespiratory functions in ASD to elucidate the physiologic basis of behaviors. Methods: Nineteen children with ASD and 18 age matched controls underwent autonomic function monitoring at a defined resting state using the NeuroScope. The non-invasive real time beat-to-beat blood pressure was measured by Portapres and fed into the NeuroScope where heart rate, cardiac vagal tone and cardiac sensitivity to baroreceptor were derived from the EKG and blood pressure waveforms using the Vagosoft software; and respiratory rate and rhythm were measured simultaneously by plethysmograph. Respiration was analyzed breath by breath using our prior published methods. Results: Various respiratory dysrhythmias, particularly Biot's and Cheyne-Stokes respiration, were detected in children with ASD, who also exhibited greater variability in respiratory rhythm and amplitudes than controls. The respiratory dysrhythmia in children with ASD was associated with a lower cardiac vagal activity. Conclusion: The Biot's breathing and Cheyne-Stokes respiration coupled with cardiac vagal hypofunction in ASD suggest a brainstem dysfunction consistent with our previous findings. The low parasympathetic activity could explain in part the chronic sensory hyperarousal state in children with ASD.

Original languageEnglish (US)
Pages (from-to)225-232
Number of pages8
JournalBrain and Development
Volume38
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Cheyne-Stokes Respiration
Respiration
Blood Pressure
Pressoreceptors
Autism Spectrum Disorder
Respiratory Rate
Brain Stem
Electrocardiography
Software
Heart Rate

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Keywords

  • Autism spectrum disorders
  • Autonomic dysfunction
  • Biot's breathing
  • Cheyne-Stokes respiration
  • Respiratory dysrhythmia

Cite this

Ming, Xue ; Patel, Ritesh ; Kang, Victor ; Chokroverty, Sudhansu ; Julu, Peter O. / Respiratory and autonomic dysfunction in children with autism spectrum disorders. In: Brain and Development. 2016 ; Vol. 38, No. 2. pp. 225-232.
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Respiratory and autonomic dysfunction in children with autism spectrum disorders. / Ming, Xue; Patel, Ritesh; Kang, Victor; Chokroverty, Sudhansu; Julu, Peter O.

In: Brain and Development, Vol. 38, No. 2, 01.02.2016, p. 225-232.

Research output: Contribution to journalArticle

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