Respiratory Complications of Pediatric Neuromuscular Diseases

John R. Bach, Nelson L. Turcios, Liping Wang

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Respiration is an event of oxygen consumption and carbon dioxide production. Respiratory failure is common in pediatric neuromuscular diseases and the main cause of morbidity and mortality. It is a consequence of lung failure, ventilatory pump failure, or their combination. Lung failure often is due to chronic aspiration either from above or from below. It may lead to end-stage lung disease. Ventilatory pump failure is caused by increased respiratory load and progressive respiratory muscles weakness. This article reviews the normal function of the respiratory pump, general pathophysiology issues, abnormalities in the more common neuromuscular conditions and noninvasive interventions.

Original languageEnglish (US)
Pages (from-to)177-191
Number of pages15
JournalPediatric Clinics of North America
Issue number1
StatePublished - Feb 2021

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health


  • mechanical insufflation exsufflation
  • muscular dystrophy
  • noninvasive ventilation
  • noninvasive ventilatory support
  • pediatric neuromuscular disease
  • respiratory management
  • spinal muscular atrophy


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