Response to novel environment following septal lesions or cholinergic blockage in rats

David A. Feigley, Leonard W. Hamilton

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Compared rates of habituation of an exploratory head-poke response for 48 control, 16 septally lesioned, and 16 scopolamine-hydrobromide-injected male albino holtzman rats. Controls exhibited decreasing response rates and increasing durations/response within sessions. Response-contingent light presentation attenuated both effects and had an activating rather than a direct reinforcing effect. Both the scopolamine-hydrobromide-injected ss and ss with septal lesions showed decreasing response rates similar to controls; however, neither increased their durations/response, suggesting a more profound impairment of habituation. Both reacted to response-contingent light presentation similarly to controls but in a more exaggerated fashion indicating that an increased responsivity to response-produced stimulus feedback caused the habituation deficit. (PsycINFO Database Record (c) 2006 APA, all rights reserved).

Original languageEnglish (US)
Pages (from-to)496-504
Number of pages9
JournalJournal of comparative and physiological psychology
Issue number3
StatePublished - Sep 1971

All Science Journal Classification (ASJC) codes

  • Medicine(all)


  • septal lesions vs. cholinergic blockage, response to novel environment, rat


Dive into the research topics of 'Response to novel environment following septal lesions or cholinergic blockage in rats'. Together they form a unique fingerprint.

Cite this