Restoring Endogenous Repair Mechanisms to Heal Chronic Wounds with a Multifunctional Wound Dressing

Rahimeh B. Atashgah, Amir Ghasemi, Mohammad Raoufi, Mohammad Amin Abdollahifar, Steven Zanganeh, Hossein Nejadnik, Alieh Abdollahi, Shahriar Sharifi, Baltazar Lea, Miguel Cuerva, Mehdi Akbarzadeh, Carmen Alvarez-Lorenzo, Seyed Nasser Ostad, Andrea S. Theus, Doris L. Larock, Christopher N. Larock, Vahid Serpooshan, Rouzbeh Sarrafi, Ki Bum Lee, Hojatollah ValiHolger Schönherr, Lisa Gould, Pablo Taboada, Morteza Mahmoudi

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Current treatment of chronic wounds has been critically limited by various factors, including bacterial infection, biofilm formation, impaired angiogenesis, and prolonged inflammation. Addressing these challenges, we developed a multifunctional wound dressing-based three-pronged approach for accelerating wound healing. The multifunctional wound dressing, composed of nanofibers, functional nanoparticles, natural biopolymers, and selected protein and peptide, can target multiple endogenous repair mechanisms and represents a promising alternative to current wound healing products.

Original languageEnglish (US)
Pages (from-to)3171-3180
Number of pages10
JournalMolecular pharmaceutics
Volume18
Issue number8
DOIs
StatePublished - Aug 2 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

Keywords

  • chronic wounds
  • endogenous repair
  • multifunctional wound dressing
  • nanomedicine

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