Review of environmental factors and juvenile idiopathic arthritis

Daniel B. Horton, Susan Shenoi

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Juvenile idiopathic arthritis is a common rheumatic disease that presents as chronic childhood arthritis. JIA is considered a multifactorial disease that may result from diverse genetic and environmental risk factors. A minority of the population-attributable risk of JIA is estimated to be due to familial factors. Thus, non-genetic or environmental factors likely account for a majority of the risk of developing JIA. Yet, while substantial data have linked environmental factors to the development of rheumatoid arthritis, similar evidence regarding JIA is sparse. This narrative review provides updates on recent literature about environmental factors that might influence the risk of developing JIA, including studies about potentially beneficial and harmful influences as well as factors with unclear effects.

Original languageEnglish (US)
Pages (from-to)253-267
Number of pages15
JournalOpen Access Rheumatology: Research and Reviews
StatePublished - 2019

All Science Journal Classification (ASJC) codes

  • Rheumatology


  • Antibiotics
  • Breast feeding
  • Cesarean section
  • Environmental exposure
  • Juvenile arthritis
  • Risk factors


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