@article{9503ff803a514d26b10ea0c096f82e73,
title = "Rh(III)-catalyzed C-H amidation of 2-arylindoles with dioxazolones: A route to indolo[1,2-c]quinazolines",
abstract = "Rhodium(III)-catalyzed C-H amidation of 2-arylindoles with dioxazolones for the synthesis of indolo[1,2-c]quinazolines is reported. The reaction is compatible with a wide range of electronically diverse 2-arylindoles and dioxazolones, providing indolo[1,2-c]quinazolines in high to excellent yields. Most notably, the combination of this Rh-catalyzed C-H amidation and intramolecular N-H/N-C(O) cyclization enables the most straightforward direct route to indolo[1,2-c]quinazolines to date. Mechanistic studies and evaluation of antitumor activity of these high value heterocycles are disclosed.",
author = "Xiaogang Wang and Jin Zhang and Di Chen and Bo Wang and Xiufang Yang and Yangmin Ma and Michal Szostak",
note = "Funding Information: J.Z. thanks the China Scholarship Council (No. 201808610096). Financial support was provided by the Foundation for Young Scholars of Shaanxi University of Science and Technology (No. BJ12-26). M.S. thanks Rutgers University and the NSF (CAREER CHE-1650766). Funding Information: J.Z. thanks the China Scholarship Council (No. 201808610096). Financial support was provided by the Foundation for Young Scholars of Shaanxi University of Science and Technology (No. BJ12-26). M.S. thanks Rutgers University and the NSF (CAREER CHE-1650766). Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",
year = "2019",
month = sep,
day = "6",
doi = "10.1021/acs.orglett.9b02615",
language = "English (US)",
volume = "21",
pages = "7038--7043",
journal = "Organic letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "17",
}