Ribosome fate during decoding of uga-sec codons

Paul R. Copeland, Michael T. Howard

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Decoding of genetic information into polypeptides occurs during translation, generally following the codon assignment rules of the organism’s genetic code. However, recoding signals in certain mRNAs can overwrite the normal rules of translation. An exquisite example of this occurs during translation of selenoprotein mRNAs, wherein UGA codons are reassigned to encode for the 21st proteogenic amino acid, selenocysteine. In this review, we will examine what is known about the mechanisms of UGA recoding and discuss the fate of ribosomes that fail to incorporate selenocysteine.

Original languageEnglish (US)
Article number13204
JournalInternational journal of molecular sciences
Issue number24
StatePublished - Dec 1 2021

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


  • Nonsense-mediated decay
  • Recoding
  • Ribosome rescue
  • SECIS-binding protein
  • Selenocysteine
  • Selenoprotein
  • Translation termi-nation


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