Ribosome fate during decoding of uga-sec codons

Paul R. Copeland; Michael T. Howard

doi:10.3390/ijms222413204

Ribosome fate during decoding of uga-sec codons

Paul R. Copeland, Michael T. Howard

Robert Wood Johnson Medical School (RWJMS), Biochemistry & Molecular Biology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Decoding of genetic information into polypeptides occurs during translation, generally following the codon assignment rules of the organism’s genetic code. However, recoding signals in certain mRNAs can overwrite the normal rules of translation. An exquisite example of this occurs during translation of selenoprotein mRNAs, wherein UGA codons are reassigned to encode for the 21st proteogenic amino acid, selenocysteine. In this review, we will examine what is known about the mechanisms of UGA recoding and discuss the fate of ribosomes that fail to incorporate selenocysteine.

Original language	English (US)
Article number	13204
Journal	International journal of molecular sciences
Volume	22
Issue number	24
DOIs	https://doi.org/10.3390/ijms222413204
State	Published - Dec 1 2021

All Science Journal Classification (ASJC) codes

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

Keywords

Nonsense-mediated decay
Recoding
Ribosome rescue
SECIS
SECIS-binding protein
Selenocysteine
Selenoprotein
Translation termi-nation

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10.3390/ijms222413204

Cite this

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title = "Ribosome fate during decoding of uga-sec codons",

abstract = "Decoding of genetic information into polypeptides occurs during translation, generally following the codon assignment rules of the organism{\textquoteright}s genetic code. However, recoding signals in certain mRNAs can overwrite the normal rules of translation. An exquisite example of this occurs during translation of selenoprotein mRNAs, wherein UGA codons are reassigned to encode for the 21st proteogenic amino acid, selenocysteine. In this review, we will examine what is known about the mechanisms of UGA recoding and discuss the fate of ribosomes that fail to incorporate selenocysteine.",

keywords = "Nonsense-mediated decay, Recoding, Ribosome rescue, SECIS, SECIS-binding protein, Selenocysteine, Selenoprotein, Translation termi-nation",

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note = "Funding Information: Funding: This research was funded by the National Institutes of Health, grant number R01GM114291 (M.T.H.) and GM077073 (P.R.C.). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Howard, Michael T.

N1 - Funding Information: Funding: This research was funded by the National Institutes of Health, grant number R01GM114291 (M.T.H.) and GM077073 (P.R.C.). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/12/1

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N2 - Decoding of genetic information into polypeptides occurs during translation, generally following the codon assignment rules of the organism’s genetic code. However, recoding signals in certain mRNAs can overwrite the normal rules of translation. An exquisite example of this occurs during translation of selenoprotein mRNAs, wherein UGA codons are reassigned to encode for the 21st proteogenic amino acid, selenocysteine. In this review, we will examine what is known about the mechanisms of UGA recoding and discuss the fate of ribosomes that fail to incorporate selenocysteine.

AB - Decoding of genetic information into polypeptides occurs during translation, generally following the codon assignment rules of the organism’s genetic code. However, recoding signals in certain mRNAs can overwrite the normal rules of translation. An exquisite example of this occurs during translation of selenoprotein mRNAs, wherein UGA codons are reassigned to encode for the 21st proteogenic amino acid, selenocysteine. In this review, we will examine what is known about the mechanisms of UGA recoding and discuss the fate of ribosomes that fail to incorporate selenocysteine.

KW - Nonsense-mediated decay

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KW - Ribosome rescue

KW - SECIS

KW - SECIS-binding protein

KW - Selenocysteine

KW - Selenoprotein

KW - Translation termi-nation

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Ribosome fate during decoding of uga-sec codons

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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