Rifampin therapy in rheumatoid arthritis

Sherine Gabriel, D. L. Conn, H. Luthra

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Several second-line antirheumatic agents possess both immunosuppressive and antimicrobial properties. Rifampin is an antimicrobial agent recently found to exhibit immunosuppressive activity in both animal and human studies. Intraarticular rifamycin SV, a rifampin derivative, has been reported to cause dramatic improvement in gonarthritis in 15 patients with rheumatoid arthritis (RA). These reports along with the personal observation of spontaneous improvement of arthritic symptoms in 2 patients with RA treated with rifampin at our institution, prompted us to conduct a pilot study using oral rifampin at 600-1200 mg daily in 8 patients with active, adult onset, seropositive RA. Although, no clinically important or statistically significant improvement occurred in any of the outcome variables measured (p > 0.12), the power of this study to detect such differences was limited. Alkaline phosphatase increased modestly in 7 patients. One patient developed an acute, drug induced, flu-like syndrome with marked elevation of liver enzymes which resolved promptly with drug withdrawal. We conclude that the potential effectiveness of oral rifampin therapy in RA is doubtful.

Original languageEnglish (US)
Pages (from-to)163-166
Number of pages4
JournalJournal of Rheumatology
Volume17
Issue number2
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Rifampin
Rheumatoid Arthritis
Immunosuppressive Agents
Therapeutics
Antirheumatic Agents
Anti-Infective Agents
Pharmaceutical Preparations
Arthritis
Alkaline Phosphatase
Observation
Liver
Enzymes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology

Cite this

Gabriel, S., Conn, D. L., & Luthra, H. (1990). Rifampin therapy in rheumatoid arthritis. Journal of Rheumatology, 17(2), 163-166.
Gabriel, Sherine ; Conn, D. L. ; Luthra, H. / Rifampin therapy in rheumatoid arthritis. In: Journal of Rheumatology. 1990 ; Vol. 17, No. 2. pp. 163-166.
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Gabriel, S, Conn, DL & Luthra, H 1990, 'Rifampin therapy in rheumatoid arthritis', Journal of Rheumatology, vol. 17, no. 2, pp. 163-166.

Rifampin therapy in rheumatoid arthritis. / Gabriel, Sherine; Conn, D. L.; Luthra, H.

In: Journal of Rheumatology, Vol. 17, No. 2, 01.01.1990, p. 163-166.

Research output: Contribution to journalArticle

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Gabriel S, Conn DL, Luthra H. Rifampin therapy in rheumatoid arthritis. Journal of Rheumatology. 1990 Jan 1;17(2):163-166.