Right place, right time, right peptide: DO keeps DM focused

Lisa K. Denzin, Jennifer L. Fallas, Maria Prendes, Woelsung Yi

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


Peptide loading of major histocompatibility class II molecules is catalyzed in late endosomal and lysosomal compartments of cells by the catalytic action of human leukocyte antigen (HLA)-DM (H-2M in mice). In B cells, dendritic cells and thymic epithelial cells, the peptide loading of class II molecules is modified by the expression of the non-classical class II molecule, HLA-DO (H-2O in mice). Collectively, studies to date support that DO/H-2O expression inhibits the presentation of antigens acquired by cells via fluid phase endocytosis. However, in B cells, the expression of H-2O promotes the presentation of antigens internalized by the B-cell receptor. In this review, we summarize the literature pertaining to DO assembly, transport, and function, with an emphasis on the function of DO/H-2O.

Original languageEnglish (US)
Pages (from-to)279-292
Number of pages14
JournalImmunological Reviews
StatePublished - Oct 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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