Rise in insulin resistance is associated with escalated telomere attrition

Jeffrey P. Gardner, Shengxu Li, Sathanur R. Srinivasan, Wei Chen, Masayuki Kimura, Xiaobin Lu, Gerald S. Berenson, Abraham Aviv

Research output: Contribution to journalArticle

276 Scopus citations

Abstract

Background - Insulin resistance predisposes to cardiovascular disease and shortens human lifespan. We therefore tested the hypothesis that a rise in insulin resistance in concert with gain in body mass is associated with accelerated white blood cell telomere attrition. Methods and Results - We measured white blood cell telomere dynamics and age-related changes in insulin resistance and body mass index in young adults of the Bogalusa Heart Study. Over 10.1 to 12.8 years, the relative changes in telomere length were correlated with the homeostasis model assessment of insulin resistance (r=-0.531, P<0.001) and changes in the body mass index (r=-0.423, P<0.001). Conclusions - These findings provide the first tangible nexus of telomere biology with insulin resistance and adiposity in humans.

Original languageEnglish (US)
Pages (from-to)2171-2177
Number of pages7
JournalCirculation
Volume111
Issue number17
DOIs
StatePublished - May 3 2005

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Keywords

  • Aging
  • Insulin
  • Obesity
  • Stress
  • Telomere

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  • Cite this

    Gardner, J. P., Li, S., Srinivasan, S. R., Chen, W., Kimura, M., Lu, X., Berenson, G. S., & Aviv, A. (2005). Rise in insulin resistance is associated with escalated telomere attrition. Circulation, 111(17), 2171-2177. https://doi.org/10.1161/01.CIR.0000163550.70487.0B