Abstract
The behavioral and neurochemical effects of high doses of amphetamine administered to BALB/c mice were examined in the presence and absence of co-administered haloperidol (a D2 antagonist), SCH 23390 (a D 1 antagonist) and risperidone (a mixed 5-HT2/D 2 antagonist). It was observed that mice displayed a dose-dependent increase in stereotypic behavior, oral dyskinesia, and self-injurious behavior (SIB) in response to amphetamine treatment. Furthermore, agents that blocked the SIB reversed the amphetamine-induced release of serotonin. This effect was unrelated to hyperthermia or non-specific sedation (as assessed by measurement of motor activity). These data are interpreted in the context of the underlying basis of murine SIB involving both dopaminergic and serotonergic activation and demonstrate the efficacy of risperidone in treating these behaviors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 700-708 |
| Number of pages | 9 |
| Journal | Neuropharmacology |
| Volume | 46 |
| Issue number | 5 |
| DOIs | |
| State | Published - Apr 1 2004 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Cellular and Molecular Neuroscience
Keywords
- Autism
- Dopamine
- Mice
- Risperidone
- Self-injurious behavior
- Serotonin
Cite this
}
Risperidone reduction of amphetamine-induced self-injurious behavior in mice. / Wagner, George; Avena, Nicole; Kita, Taizo; Nakashima, Toshikatsu; Fisher, Hans; Halladay, Alycia K.
In: Neuropharmacology, Vol. 46, No. 5, 01.04.2004, p. 700-708.Research output: Contribution to journal › Article
TY - JOUR
T1 - Risperidone reduction of amphetamine-induced self-injurious behavior in mice
AU - Wagner, George
AU - Avena, Nicole
AU - Kita, Taizo
AU - Nakashima, Toshikatsu
AU - Fisher, Hans
AU - Halladay, Alycia K.
PY - 2004/4/1
Y1 - 2004/4/1
N2 - The behavioral and neurochemical effects of high doses of amphetamine administered to BALB/c mice were examined in the presence and absence of co-administered haloperidol (a D2 antagonist), SCH 23390 (a D 1 antagonist) and risperidone (a mixed 5-HT2/D 2 antagonist). It was observed that mice displayed a dose-dependent increase in stereotypic behavior, oral dyskinesia, and self-injurious behavior (SIB) in response to amphetamine treatment. Furthermore, agents that blocked the SIB reversed the amphetamine-induced release of serotonin. This effect was unrelated to hyperthermia or non-specific sedation (as assessed by measurement of motor activity). These data are interpreted in the context of the underlying basis of murine SIB involving both dopaminergic and serotonergic activation and demonstrate the efficacy of risperidone in treating these behaviors.
AB - The behavioral and neurochemical effects of high doses of amphetamine administered to BALB/c mice were examined in the presence and absence of co-administered haloperidol (a D2 antagonist), SCH 23390 (a D 1 antagonist) and risperidone (a mixed 5-HT2/D 2 antagonist). It was observed that mice displayed a dose-dependent increase in stereotypic behavior, oral dyskinesia, and self-injurious behavior (SIB) in response to amphetamine treatment. Furthermore, agents that blocked the SIB reversed the amphetamine-induced release of serotonin. This effect was unrelated to hyperthermia or non-specific sedation (as assessed by measurement of motor activity). These data are interpreted in the context of the underlying basis of murine SIB involving both dopaminergic and serotonergic activation and demonstrate the efficacy of risperidone in treating these behaviors.
KW - Autism
KW - Dopamine
KW - Mice
KW - Risperidone
KW - Self-injurious behavior
KW - Serotonin
UR - http://www.scopus.com/inward/record.url?scp=1442348877&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1442348877&partnerID=8YFLogxK
U2 - 10.1016/j.neuropharm.2003.11.009
DO - 10.1016/j.neuropharm.2003.11.009
M3 - Article
C2 - 14996547
AN - SCOPUS:1442348877
VL - 46
SP - 700
EP - 708
JO - Neuropharmacology
JF - Neuropharmacology
SN - 0028-3908
IS - 5
ER -