Risperidone reduction of amphetamine-induced self-injurious behavior in mice

George Wagner, Nicole Avena, Taizo Kita, Toshikatsu Nakashima, Hans Fisher, Alycia K. Halladay

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The behavioral and neurochemical effects of high doses of amphetamine administered to BALB/c mice were examined in the presence and absence of co-administered haloperidol (a D2 antagonist), SCH 23390 (a D 1 antagonist) and risperidone (a mixed 5-HT2/D 2 antagonist). It was observed that mice displayed a dose-dependent increase in stereotypic behavior, oral dyskinesia, and self-injurious behavior (SIB) in response to amphetamine treatment. Furthermore, agents that blocked the SIB reversed the amphetamine-induced release of serotonin. This effect was unrelated to hyperthermia or non-specific sedation (as assessed by measurement of motor activity). These data are interpreted in the context of the underlying basis of murine SIB involving both dopaminergic and serotonergic activation and demonstrate the efficacy of risperidone in treating these behaviors.

Original languageEnglish (US)
Pages (from-to)700-708
Number of pages9
JournalNeuropharmacology
Volume46
Issue number5
DOIs
StatePublished - Apr 1 2004

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cellular and Molecular Neuroscience

Keywords

  • Autism
  • Dopamine
  • Mice
  • Risperidone
  • Self-injurious behavior
  • Serotonin

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