RNA polymerase II: subunit structure and function

Nancy A. Woychik, Richard A. Young

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

RNA polymerase II is the core of the complex apparatus that is responsible for the regulated synthesis of mRNA. A comprehensive knowledge of RNA polymerase II is essential to our understanding of the molecular mechanisms through which a variety of transcription factors regulate eukaryotic gene expression. The recent cloning of genes for all ten subunits of yeast RNA polymerase II has revealed intriguing similarities and differences between the eukaryotic RNA polymerase and its simpler prokaryotic counterpart. Epitope tagging and other experiments made possible by the cloning of these genes have provided a clearer picture of RNA polymerase II subunit composition, stoichiometry and function, and set the stage for further investigating the dialogue between RNA polymerase II and transcription factors.

Original languageEnglish (US)
Pages (from-to)347-351
Number of pages5
JournalTrends in Biochemical Sciences
Volume15
Issue number9
DOIs
StatePublished - Sep 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Fingerprint

Dive into the research topics of 'RNA polymerase II: subunit structure and function'. Together they form a unique fingerprint.

Cite this