Role of apolipoprotein E polymorphism as a prognostic marker in traumatic brain injury and neurodegenerative disease: A critical review

Tanmoy Kumar Maiti, Subhas Konar, Shyamal Bir, Piyush Kalakoti, Papireddy Bollam, Anil Nanda

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Object The difference in course and outcome of several neurodegenerative conditions and traumatic injuries of the nervous system points toward a possible role of genetic and environmental factors as prognostic markers. Apolipoprotein E(Apo-E), a key player in lipid metabolism, is recognized as one of the most powerful genetic risk factors for dementia and other neurodegenerative diseases. In this article, the current understanding of APOE polymorphism in various neurological disorders is discussed. Methods The English literature was searched for various studies describing the role of APOE polymorphism as a prognosticmarker in neurodegenerative diseases and traumatic brain injury. The wide ethnic distribution of APOE polymorphism was discussed, and the recent meta-analyses of role of APOE polymorphism in multiple diseases were analyzed and summarized intabular form. Results Results from the review of literature revealed that the distribution of APOE is varied in different ethnic populations. APOE polymorphism plays a significant role in pathogenesis of neurodegeneration, particularly in Alzheimer's disease. APOE e{open}4 is considered a marker for poor prognosis in various diseases, but APOE e{open}2 rather than APOE e{open}4 has been associated with cerebral amyloid angiopathy-related bleeding and sporadic Parkinson's disease. The role of APOE polymorphism in various neurological diseases has not been conclusively elucidated. Conclusions Apo-E is a biomarker for various neurological and systemic diseases. Therefore, while analyzing the role of APOE polymorphism in neurological diseases, the interpretation should be done after adjusting all the confounding factors. A continuous quest to look for associations with various neurological diseases and wide knowledge of available literature are required to improve the understanding of the role of APOE polymorphism in these conditions and identify potential therapeutic targets.

Original languageEnglish (US)
Article numberE3
JournalNeurosurgical focus
Volume39
Issue number5
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Neurodegenerative disease
  • Traumatic brain injury

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