Role of dietary bioactive natural products in estrogen receptor-positive breast cancer

Min Ji Bak, Soumyasri Das Gupta, Joseph Wahler, Nanjoo Suh

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Estrogen receptor (ER)-positive breast cancer, including luminal-A and -B, is the most common type of breast cancer. Extended exposure to estrogen is associated with an increased risk of breast cancer. Both ER-dependent and ER-independent mechanisms have been implicated in estrogen-mediated carcinogenesis. The ER-dependent pathway involves cell growth and proliferation triggered by the binding of estrogen to the ER. The ER-independent mechanisms depend on the metabolism of estrogen to generate genotoxic metabolites, free radicals and reactive oxygen species to induce breast cancer. A better understanding of the mechanisms that drive ER-positive breast cancer will help optimize targeted approaches to prevent or treat breast cancer. A growing emphasis is being placed on alternative medicine and dietary approaches toward the prevention and treatment of breast cancer. Many natural products and bioactive compounds found in foods have been shown to inhibit breast carcinogenesis via inhibition of estrogen induced oxidative stress as well as ER signaling. This review summarizes the role of bioactive natural products that are involved in the prevention and treatment of estrogen-related and ER-positive breast cancer.

Original languageEnglish (US)
Pages (from-to)170-191
Number of pages22
JournalSeminars in Cancer Biology
Volume40_41
DOIs
StatePublished - Oct 1 2016

Fingerprint

Biological Products
Estrogen Receptors
Breast Neoplasms
Estrogens
Carcinogenesis
Complementary Therapies
Free Radicals
Reactive Oxygen Species
Oxidative Stress
Breast
Cell Proliferation
Food
Therapeutics
Growth

All Science Journal Classification (ASJC) codes

  • Cancer Research

Keywords

  • Bioactive natural compounds
  • Breast cancer
  • Estrogen
  • Oxidative stress
  • Stem cells

Cite this

Bak, Min Ji ; Das Gupta, Soumyasri ; Wahler, Joseph ; Suh, Nanjoo. / Role of dietary bioactive natural products in estrogen receptor-positive breast cancer. In: Seminars in Cancer Biology. 2016 ; Vol. 40_41. pp. 170-191.
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Role of dietary bioactive natural products in estrogen receptor-positive breast cancer. / Bak, Min Ji; Das Gupta, Soumyasri; Wahler, Joseph; Suh, Nanjoo.

In: Seminars in Cancer Biology, Vol. 40_41, 01.10.2016, p. 170-191.

Research output: Contribution to journalReview article

TY - JOUR

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AU - Bak, Min Ji

AU - Das Gupta, Soumyasri

AU - Wahler, Joseph

AU - Suh, Nanjoo

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N2 - Estrogen receptor (ER)-positive breast cancer, including luminal-A and -B, is the most common type of breast cancer. Extended exposure to estrogen is associated with an increased risk of breast cancer. Both ER-dependent and ER-independent mechanisms have been implicated in estrogen-mediated carcinogenesis. The ER-dependent pathway involves cell growth and proliferation triggered by the binding of estrogen to the ER. The ER-independent mechanisms depend on the metabolism of estrogen to generate genotoxic metabolites, free radicals and reactive oxygen species to induce breast cancer. A better understanding of the mechanisms that drive ER-positive breast cancer will help optimize targeted approaches to prevent or treat breast cancer. A growing emphasis is being placed on alternative medicine and dietary approaches toward the prevention and treatment of breast cancer. Many natural products and bioactive compounds found in foods have been shown to inhibit breast carcinogenesis via inhibition of estrogen induced oxidative stress as well as ER signaling. This review summarizes the role of bioactive natural products that are involved in the prevention and treatment of estrogen-related and ER-positive breast cancer.

AB - Estrogen receptor (ER)-positive breast cancer, including luminal-A and -B, is the most common type of breast cancer. Extended exposure to estrogen is associated with an increased risk of breast cancer. Both ER-dependent and ER-independent mechanisms have been implicated in estrogen-mediated carcinogenesis. The ER-dependent pathway involves cell growth and proliferation triggered by the binding of estrogen to the ER. The ER-independent mechanisms depend on the metabolism of estrogen to generate genotoxic metabolites, free radicals and reactive oxygen species to induce breast cancer. A better understanding of the mechanisms that drive ER-positive breast cancer will help optimize targeted approaches to prevent or treat breast cancer. A growing emphasis is being placed on alternative medicine and dietary approaches toward the prevention and treatment of breast cancer. Many natural products and bioactive compounds found in foods have been shown to inhibit breast carcinogenesis via inhibition of estrogen induced oxidative stress as well as ER signaling. This review summarizes the role of bioactive natural products that are involved in the prevention and treatment of estrogen-related and ER-positive breast cancer.

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